Kantarci Kejal, Kapoor Ekta, Geske Jennifer R, Castillo Anna, Fields Julie A, Kara Firat, Knyazhanskaya Evdokiya E, Schwarz Christopher G, Senjem Matthew L, Bailey Kent R, Lowe Val, LeBrasseur Nathan K, Rocca Walter A, Mielke Michelle M
Department of Radiology, Division of Neuroradiology, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic Women's Health Research Center, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement. 2024 Dec 23. doi: 10.1002/alz.14469.
Premenopausal bilateral oophorectomy (PBO) before the age of 46 years is associated with an increased risk of dementia. We investigated the long-term effects of PBO performed before age 50 years on amyloid beta (Aβ), tau, and neurodegeneration imaging biomarkers of Alzheimer's disease (AD).
Mayo Clinic Cohort Study of Oophorectomy and Aging-2 participants were divided into early PBO (< 46 years; n = 61), and late PBO (46-49 years; n = 51) groups and were compared to referent women who did not undergo PBO (n = 119).
Early PBO was associated with thinner entorhinal cortex (p = 0.014), higher tau load at higher levels of Aβ load (Pp = 0.005), higher Aβ load (p = 0.026), and smaller temporal lobe cortical thickness (p = 0.022), only at older ages compared to the referent group.
PBO before the age of 46 years is associated with entorhinal cortex thinning, elevated tau at higher Aβ levels, along with an AD-like pattern of atrophy at older ages.
NCT03821857 sex-specific effects of endocrine disruption on aging and AD.
Premenopausal bilateral oophorectomy (PBO) before the ages of 46 (early PBO) years and ages 46 to 49 (late PBO) years was studied. Early PBO was associated with reduced entorhinal cortex thickness later in life. Early PBO was associated with greater amyloid beta (Aβ) load at older ages. Early PBO was associated with greater Alzheimer's disease pattern of atrophy at older ages. Early PBO was associated with higher tau load at higher Aβ levels.
46岁之前进行的绝经前双侧卵巢切除术（PBO）与痴呆风险增加相关。我们研究了50岁之前进行PBO对阿尔茨海默病（AD）的淀粉样蛋白β（Aβ）、tau和神经退行性变成像生物标志物的长期影响。
梅奥诊所卵巢切除术与衰老队列研究-2的参与者被分为早期PBO组（<46岁；n = 61）和晚期PBO组（46 - 49岁；n = 51），并与未接受PBO的对照女性（n = 119）进行比较。
仅在老年时，与对照组相比，早期PBO与内嗅皮质变薄（p = 0.014）、在较高Aβ负荷水平时tau负荷较高（Pp = 0.005）、Aβ负荷较高（p = 0.026）以及颞叶皮质厚度较小（p = 0.022）相关。
46岁之前进行PBO与内嗅皮质变薄、在较高Aβ水平时tau升高以及老年时类似AD的萎缩模式相关。
NCT03821857内分泌干扰对衰老和AD 的性别特异性影响。
研究了46岁（早期PBO）和46至49岁（晚期PBO）之前的绝经前双侧卵巢切除术。早期PBO与晚年内嗅皮质厚度减小相关。早期PBO与老年时更高的淀粉样蛋白β（Aβ）负荷相关。早期PBO与老年时更明显的阿尔茨海默病萎缩模式相关。早期PBO与在较高Aβ水平时更高的tau负荷相关。
