Zhang Zhiyu, Xu Lin, Xu Sheng
Emergency Department, Brain Hospital of Hunan Province (The Second People's Hospital of Hunan Province), Changsha, Hunan, People's Republic of China.
Department of Pediatrics, Brain Hospital of Hunan Province (The Second People's Hospital of Hunan Province), Changsha, Hunan, People's Republic of China.
Ther Clin Risk Manag. 2025 May 2;21:609-619. doi: 10.2147/TCRM.S512780. eCollection 2025.
Severe traumatic brain injury (TBI) patients undergoing emergency craniotomy are at high risk of postoperative infections. This study aims to identify the risk factors associated with these infections to improve patient outcomes.
A retrospective cohort study was conducted, including 312 severe TBI patients who underwent emergency craniotomy at Brain Hospital of Hunan Province between December 2019 and December 2021. Clinical data were collected, and both univariate and multivariate logistic regression analyses were performed to identify risk factors for postoperative infections.
Among the 312 patients, 57 (18.3%) developed postoperative infections. Multivariate analysis identified several significant risk factors, including older age (OR=1.75, 95% CI: 1.23-2.49), prolonged surgery duration (OR=2.01, 95% CI: 1.38-2.92), presence of preoperative infection (OR=2.59, 95% CI: 1.64-4.09), and lower Glasgow Coma Scale (GCS) score on admission (OR=1.82, 95% CI: 1.21-2.74).
Identifying patients at high risk for postoperative infections can help guide preventive measures and improve outcomes in severe TBI patients undergoing emergency craniotomy.
接受急诊开颅手术的重型颅脑损伤（TBI）患者术后感染风险较高。本研究旨在确定与这些感染相关的危险因素，以改善患者预后。
进行了一项回顾性队列研究，纳入2019年12月至2021年12月在湖南省脑科医院接受急诊开颅手术的312例重型TBI患者。收集临床数据，并进行单因素和多因素逻辑回归分析，以确定术后感染的危险因素。
在312例患者中，57例（18.3%）发生了术后感染。多因素分析确定了几个显著的危险因素，包括年龄较大（OR=1.75，95%CI：1.23-2.49）、手术时间延长（OR=2.01，95%CI：1.38-2.92）、术前存在感染（OR=2.59，95%CI：1.64-4.09）以及入院时格拉斯哥昏迷量表（GCS）评分较低（OR=1.82，95%CI：1.21-2.74）。
识别术后感染高危患者有助于指导预防措施，改善接受急诊开颅手术的重型TBI患者的预后。
