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一例膀胱小细胞癌经联合化疗和放疗后肿瘤显著缩小的病例。

A Case of Small Cell Carcinoma of Bladder With Significant Tumor Reduction Following Combination Chemotherapy and Radiation Therapy.

作者信息

Yoshitake Rintaro, Taguchi Syunsuke, Harada Yoshimasa

机构信息

Nagahama Red Cross Hospital Nagahama Japan.

Hikone Municipal Hospital Hikone Japan.

出版信息

IJU Case Rep. 2025 Apr 14;8(3):289-292. doi: 10.1002/iju5.70031. eCollection 2025 May.

DOI:10.1002/iju5.70031
PMID:40336740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12055206/
Abstract

INTRODUCTION

Small cell carcinoma of the bladder (SCCB) is a rare and aggressive disease with no established standard treatment. We report a case of SCCB that initially progressed with chemotherapy but responded well to a combination of chemotherapy and radiotherapy.

CASE PRESENTATION

A 62-year-old man presented with painless gross hematuria. Transurethral resection of the bladder tumor (TURBT) confirmed SCCB. Gemcitabine-carboplatin (GEM-CBDCA) and pembrolizumab were ineffective, leading to rapid tumor progression. The patient developed bladder tamponade and obstructive renal failure. Emergency radiotherapy (30 Gy) controlled bleeding, and etoposide-carboplatin chemotherapy resulted in significant tumor shrinkage.

CONCLUSION

This case highlights the potential effectiveness of etoposide-carboplatin and radiotherapy in SCCB, especially in cases resistant to other treatments. Further studies are needed to establish optimal treatment strategies for SCCB.

摘要

引言

膀胱小细胞癌（SCCB）是一种罕见且侵袭性强的疾病，尚无既定的标准治疗方法。我们报告一例膀胱小细胞癌病例，该病例最初对化疗有进展，但对化疗与放疗联合治疗反应良好。

病例介绍

一名62岁男性出现无痛性肉眼血尿。经尿道膀胱肿瘤切除术（TURBT）确诊为膀胱小细胞癌。吉西他滨 - 卡铂（GEM - CBDCA）和帕博利珠单抗治疗无效，导致肿瘤迅速进展。患者出现膀胱填塞和梗阻性肾衰竭。紧急放疗（30 Gy）控制了出血，依托泊苷 - 卡铂化疗使肿瘤显著缩小。

结论

该病例突出了依托泊苷 - 卡铂和放疗在膀胱小细胞癌中的潜在有效性，尤其是在对其他治疗耐药的病例中。需要进一步研究以确立膀胱小细胞癌的最佳治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/12055206/5d6ea5bd8757/IJU5-8-289-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/12055206/022809ed7ce2/IJU5-8-289-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/12055206/f9ee047ec391/IJU5-8-289-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/12055206/000e9773164c/IJU5-8-289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/12055206/5d6ea5bd8757/IJU5-8-289-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/12055206/022809ed7ce2/IJU5-8-289-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/12055206/f9ee047ec391/IJU5-8-289-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/12055206/000e9773164c/IJU5-8-289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/12055206/5d6ea5bd8757/IJU5-8-289-g002.jpg

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