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红色靶区——立体定向放射外科中的高风险正常组织。

Red shell- high risk normal tissue in stereotactic radiosurgery.

作者信息

Yang Jun, Qi Weihua, Wang Lei, Lu Qiuxia, Han Liangfu, Wang Brian, Yan Weisi

机构信息

Junxin Precision Oncology Group Foshan Guangdong China.

Radiation Oncology Dept Foshan Chancheng Hospital Foshan Guangdong China.

出版信息

Precis Radiat Oncol. 2023 Dec 25;7(4):273-277. doi: 10.1002/pro6.1218. eCollection 2023 Dec.

DOI:10.1002/pro6.1218
PMID:40336873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11935186/
Abstract

Due to the ablative nature of high prescription in Stereotactic Radiosurgery or stereotactic body radiation therapy (SRS/SBRT), the normal tissue surrounding the CTV receives the dose higher than tissue's dose constraint. A concept of Red Shell is proposed to define and quantify these tissue damaged in SBRT, using biological equivalent dose (BED) concept. The combination of biological factors and physics factors, including serial and parallel organ, dose gradient, dose distribution and fractionations, are further discussed to interpret the clinical meaning of Red Shell. This concept can also help planner to improve the optimization in planning process.

摘要

由于立体定向放射外科手术或立体定向体部放射治疗(SRS/SBRT)中高处方剂量的消融性质,临床靶区(CTV)周围的正常组织接受的剂量高于组织的剂量限制。提出了“红壳”概念,以使用生物等效剂量(BED)概念来定义和量化SBRT中这些受损组织。进一步讨论了生物因素和物理因素的组合,包括串联和并联器官、剂量梯度、剂量分布和分次照射,以解释“红壳”的临床意义。这个概念还可以帮助计划者在计划过程中改进优化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/d9f07cf90944/PRO6-7-273-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/3b0c55b27d79/PRO6-7-273-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/76859fc6d62b/PRO6-7-273-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/d819b73c035a/PRO6-7-273-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/4cfc4a891a29/PRO6-7-273-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/d9f07cf90944/PRO6-7-273-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/3b0c55b27d79/PRO6-7-273-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/76859fc6d62b/PRO6-7-273-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/d819b73c035a/PRO6-7-273-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/4cfc4a891a29/PRO6-7-273-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8795/11935186/d9f07cf90944/PRO6-7-273-g003.jpg

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本文引用的文献

1
Effect of fractionation in stereotactic body radiation therapy using the linear quadratic model.立体定向体部放射治疗中应用线性二次模型的分割效应。
Int J Radiat Oncol Biol Phys. 2013 May 1;86(1):150-6. doi: 10.1016/j.ijrobp.2012.10.024. Epub 2012 Dec 11.
2
Red shell: defining a high-risk zone of normal tissue damage in stereotactic body radiation therapy.红壳:定义立体定向体部放射治疗中正常组织损伤的高危区。
Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):903-9. doi: 10.1016/j.ijrobp.2009.12.069. Epub 2010 Apr 17.
3
A "Red Shell" concept of increased radiation damage hazard to normal tissues just outside the PTV target volume.
一种关于在计划靶区(PTV)靶体积之外的正常组织辐射损伤风险增加的“红壳”概念。
Radiother Oncol. 2010 Mar;94(3):384. doi: 10.1016/j.radonc.2010.01.022. Epub 2010 Feb 19.
4
Linear quadratics is alive and well: in regard to Park et al. (Int J Radiat Oncol Biol Phys 2008;70:847-852).线性二次模型依然存在且发展良好:关于帕克等人(《国际放射肿瘤学、生物学、物理学杂志》2008年;70:847 - 852)的研究。
Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):957; author reply 958. doi: 10.1016/j.ijrobp.2008.06.1929.
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Stereotactic body radiation therapy: a comprehensive review.立体定向体部放射治疗:综述
Am J Clin Oncol. 2007 Dec;30(6):637-44. doi: 10.1097/COC.0b013e3180ca7cb1.
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The linear-quadratic formula and progress in fractionated radiotherapy.线性二次公式与分次放射治疗的进展
Br J Radiol. 1989 Aug;62(740):679-94. doi: 10.1259/0007-1285-62-740-679.