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[物质名称1]和[物质名称2]的协同提取物在东莨菪碱诱导的认知障碍模型中调节神经可塑性和氧化应激。

The synergistic extract of and regulates neuroplasticity and oxidative stress in a scopolamine-induced cognitive impairment model.

作者信息

Tran Ngoc Buu, Lee Haesung, Ji Myoung-Geun, Ngo Hoang Long, Lee Sook-Jeong

机构信息

Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Jeonbuk National University, Jeonju, Jeonbuk-do, Republic of Korea.

出版信息

Front Aging Neurosci. 2025 Apr 23;17:1566621. doi: 10.3389/fnagi.2025.1566621. eCollection 2025.

DOI:10.3389/fnagi.2025.1566621
PMID:40336947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12055851/
Abstract

INTRODUCTION

Neurodegenerative disorders, such as Alzheimer's disease, arise from neuroinflammation, which leads to cognitive and memory impairment. Scopolamine is commonly used to induce cognitive and memory deficits in mouse models.

AIMS

This study investigated the neuroprotective potential of a () and (Tm) extract mixture (ZaTm mixture) in mitigating scopolamine-induced cognitive and memory deficits in mice.

RESULTS

Behavioral assessments, including the Morris water maze, Y-maze, and light/dark tests, demonstrated that the ZaTm mixture significantly enhanced memory and cognitive function in treated mice. Furthermore, the ZaTm mixture restored the disrupted expression of choline acetyltransferase and acetylcholinesterase in the hippocampi of scopolamine-treated mice. Additionally, scopolamine-induced glutamatergic/GABAergic dysfunction was markedly improved following treatment with the ZaTm mixture. The extract also exhibited neuroprotective effects by enhancing the activity of antioxidants, such as glutathione and malondialdehyde, and key enzymes, including catalase and superoxide dismutase. Moreover, it effectively inhibited senescence in the hippocampus by modulating the AMPK/SIRT and BDNF-Akt/mTOR signaling pathways.

DISCUSSION

This study highlights the promising potential of the ZaTm extract mixture as a novel therapeutic agent and functional food for the prevention and treatment of Alzheimer's disease and other neurodegenerative disorders.

摘要

引言

神经退行性疾病，如阿尔茨海默病，源于神经炎症，可导致认知和记忆障碍。东莨菪碱常用于在小鼠模型中诱导认知和记忆缺陷。

目的

本研究调查了一种（）和（Tm）提取物混合物（ZaTm混合物）在减轻东莨菪碱诱导的小鼠认知和记忆缺陷方面的神经保护潜力。

结果

包括莫里斯水迷宫、Y迷宫和明暗试验在内的行为评估表明，ZaTm混合物显著增强了受试小鼠的记忆和认知功能。此外，ZaTm混合物恢复了东莨菪碱处理小鼠海马体中胆碱乙酰转移酶和乙酰胆碱酯酶的表达紊乱。此外，用ZaTm混合物处理后，东莨菪碱诱导的谷氨酸能/γ-氨基丁酸能功能障碍得到明显改善。该提取物还通过增强抗氧化剂（如谷胱甘肽和丙二醛）以及关键酶（包括过氧化氢酶和超氧化物歧化酶）的活性发挥神经保护作用。此外，它通过调节AMPK/SIRT和BDNF-Akt/mTOR信号通路有效抑制海马体衰老。

讨论

本研究突出了ZaTm提取物混合物作为预防和治疗阿尔茨海默病及其他神经退行性疾病的新型治疗剂和功能性食品的潜在前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/f796c3f6600b/fnagi-17-1566621-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/824ef594a5e0/fnagi-17-1566621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/692282c859cf/fnagi-17-1566621-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/959035d8ba85/fnagi-17-1566621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/a1c85c1be58c/fnagi-17-1566621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/112d65474674/fnagi-17-1566621-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/6f2174528728/fnagi-17-1566621-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/fdcf1ce2c6e4/fnagi-17-1566621-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/0f4d12dc380f/fnagi-17-1566621-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/f796c3f6600b/fnagi-17-1566621-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/824ef594a5e0/fnagi-17-1566621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/692282c859cf/fnagi-17-1566621-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/959035d8ba85/fnagi-17-1566621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/a1c85c1be58c/fnagi-17-1566621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/112d65474674/fnagi-17-1566621-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/6f2174528728/fnagi-17-1566621-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/fdcf1ce2c6e4/fnagi-17-1566621-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/0f4d12dc380f/fnagi-17-1566621-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e648/12055851/f796c3f6600b/fnagi-17-1566621-g009.jpg

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