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进退两难——心脏难题:非精原细胞瘤性生殖细胞肿瘤睾丸连续腔静脉-心房肿瘤血栓的报告

Between the Devil and the Deep Sea-The Cardiac Conundrum: Report of a Contiguous Cavo-Atrial Tumor Thrombus in NSGCT Testis.

作者信息

Venkatesh Shrinivas, Kumar Dakshinamurthy Suresh, Krishnamurthy Shalini Shree, Muralidharan Krishna, Noushad Navin, Malik Kanuj, Raja Anand

机构信息

Department of Surgical Oncology, Cancer Institute (WIA), No: 38, Sardar Patel Road, Adyar Chennai, 600036 Tamil Nadu India.

Department of Surgical Oncology, Tamil Nadu Government Multi Superspeciality Hospital, Omandurar Estate, Chennai, Tamil Nadu India.

出版信息

Indian J Surg Oncol. 2025 Apr;16(2):639-644. doi: 10.1007/s13193-024-02119-1. Epub 2024 Oct 25.

Abstract

Testicular cancer is notorious for its myriad presentations. In this case report, we present a 28-year-old gentleman diagnosed with metastatic non-seminomatous germ cell tumor (NSGCT). After receiving neoadjuvant chemotherapy, he was found to have a large paracaval conglomerate nodal mass infiltrating the inferior vena cava (IVC), with a contiguous thrombus extending from the vena cava to the right atrium. The pre-operative imaging was ambiguous, with the cavo-atrial thrombus appearing to float within the vascular lumen at some places and infiltrating the caval wall at others. Hence, arrangements were made for cardiopulmonary bypass, sternotomy, and vascular surgeon backup. Intraoperatively, the vena cava was palpated in its entirety up to the mediastinum, and the thrombus was found to be freely floating. Hence, the thrombus was milked out in its entirety from the right atrium up to the vena cava, and the paracaval mass was resected en bloc with the tumor thrombus. The IVC was reconstructed with a Dacron graft. A review of the literature revealed no previously documented cases of contiguous cavo-atrial tumor thrombus. Approaching cases requires an assessment of the nature of the thrombus and the need to prepare for the worst. It is worth remembering that going the extra mile concerning obtaining a complete tumor clearance is worth it in NSGCTs, given the highly gratifying outcomes.

摘要

睾丸癌因其多样的表现而声名狼藉。在本病例报告中,我们介绍了一位28岁被诊断为转移性非精原细胞瘤性生殖细胞肿瘤(NSGCT)的男性患者。在接受新辅助化疗后,发现他有一个巨大的腔静脉旁融合性淋巴结肿块,侵犯下腔静脉(IVC),并有一个连续的血栓从腔静脉延伸至右心房。术前影像检查结果不明确,腔房血栓在某些部位似乎漂浮在血管腔内,而在其他部位则侵犯腔静脉壁。因此,安排了体外循环、胸骨切开术,并请血管外科医生随时待命。术中,对直至纵隔的整个腔静脉进行了触诊,发现血栓是自由漂浮的。因此,将血栓从右心房一直挤到腔静脉,然后将腔静脉旁肿块与肿瘤血栓整块切除。用涤纶补片重建下腔静脉。文献回顾显示,此前没有关于连续腔房肿瘤血栓的记录病例。处理此类病例需要评估血栓的性质,并做好应对最坏情况的准备。值得记住的是,在NSGCT中,为实现肿瘤的完全清除而付出额外努力是值得的,因为其结果非常令人满意。

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本文引用的文献

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Suprahilar and Retrocrural Domains in RPLND for NSGCT Testis-Going Beyond Where the Light Touches!
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Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium.
J Clin Oncol. 2021 May 10;39(14):1563-1574. doi: 10.1200/JCO.20.03296. Epub 2021 Apr 6.
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