Henretta Sarah, Lammerding Jan
Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY USA.
Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY USA.
NPJ Biol Phys Mech. 2025;2(1):14. doi: 10.1038/s44341-025-00018-2. Epub 2025 May 5.
Breast cancer cells frequently exhibit changes in the expression of nuclear envelope (NE) proteins such as lamins and emerin that determine the physical properties of the nucleus and contribute to cellular mechanotransduction. This review explores the emerging interplay between NE proteins, the physical challenges incurred during metastatic progression, and mechanotransduction. Improved insights into the underlying mechanisms may ultimately lead to better prognostic tools and treatment strategies for metastatic breast cancer.
乳腺癌细胞经常表现出核膜（NE）蛋白表达的变化，如核纤层蛋白和emerin，这些蛋白决定了细胞核的物理特性，并有助于细胞的机械转导。本综述探讨了核膜蛋白、转移进展过程中所面临的物理挑战以及机械转导之间新出现的相互作用。对潜在机制的深入了解最终可能会带来更好的转移性乳腺癌预后工具和治疗策略。
