Celebisoy Nese, Kısabay Aysın, Özdemir Hüseyin Nezih, Gokcay Figen, Sarıtas Aysegul Seyma, Toydemir Hulya, Yayla Vıldan, Isıkay Ilksen, Erkent İrem, Atac Ceyla, Bıcakcı Sebnem, Güleç Feray, Kartı Dılek Top, Goksu Eylem Ozaydın
Department of Neurology, Ege University, Bornova, Türkiye.
Department of Neurology, Manisa Celal Bayar University, Manisa, Türkiye.
Front Neurol. 2025 Apr 10;16:1567233. doi: 10.3389/fneur.2025.1567233. eCollection 2025.
Data about the prognosis of vestibular migraine (VM) is scarce. VM patients on follow-up for at least 4 years were included in this multicenter study to evaluate the course of symptoms.
This is a cross-sectional study. A structured questionnaire was used inquiring demographic features, age of onset of migraine headaches and vertigo attacks, headache and vertigo attack frequency, severity, associated features and the presence of interictal dizziness and positional vertigo. Menopause, history of motion sickness, and family history of migraine were recorded. Answers of the first visit were compared with the answers of the last visit. In addition, variables considered were evaluated regarding their effect on the symptom course.
203 patients were studied. Median vertigo and headache attack frequency and severity had significantly dropped during follow-up ( < 0.01 for all comparisons). Complete resolution was reported by only 5.4%. Dizziness between the attacks was present in 67%, and positional vertigo was reported by 20.2%. Univariate analysis showed that aural symptoms ( = 0.013) and menopause ( = 0.016) were risk factors for ongoing frequent vertigo attacks. A history of motion sickness ( = 0.019) and a family history of migraine ( = 0.004) were associated with the risk of frequent migraine headaches. The presence of allodynia ( = 0.002) was associated with severe headache attacks while an early age of onset of vertigo attacks ( = 0.005) was a risk factor for continuing high-frequency vertigo attacks.
Though the frequency and severity of headache and vertigo attacks decrease, complete resolution is reported by a minority.
关于前庭性偏头痛（VM）预后的数据稀缺。本多中心研究纳入了随访至少4年的VM患者，以评估症状的发展过程。
这是一项横断面研究。采用结构化问卷询问人口统计学特征、偏头痛性头痛和眩晕发作的起始年龄、头痛和眩晕发作频率、严重程度、相关特征以及发作间期头晕和位置性眩晕的情况。记录绝经情况、晕动病史和偏头痛家族史。将首次就诊的答案与末次就诊的答案进行比较。此外，对所考虑的变量就其对症状发展过程的影响进行评估。
共研究了203例患者。随访期间，眩晕和头痛发作的频率及严重程度中位数显著下降（所有比较均P<0.01）。仅5.4%的患者报告症状完全缓解。67%的患者存在发作间期头晕，20.2%的患者报告有位置性眩晕。单因素分析显示，耳部症状（P=0.013）和绝经（P=0.016）是持续性频繁眩晕发作的危险因素。晕动病史（P=0.019）和偏头痛家族史（P=0.004）与频繁偏头痛性头痛的风险相关。存在痛觉过敏（P=0.002）与严重头痛发作相关，而眩晕发作起始年龄较早（P=0.005）是持续性高频眩晕发作的危险因素。
尽管头痛和眩晕发作的频率及严重程度降低，但只有少数患者报告症状完全缓解。
