Onyancha Sammy, Dettmer Isabelle, Maloku Njuxhersa, Rohde Gernot
Department of Pulmonology St. Elisabethen Krankenhaus Frankfurt Germany.
Medical Clinic I, Department of Respiratory Medicine Goethe University Frankfurt, University Hospital Frankfurt Germany.
Respirol Case Rep. 2025 May 7;13(5):e70193. doi: 10.1002/rcr2.70193. eCollection 2025 May.
Tumour seeding following biopsy is a rare but clinically significant complication in lung cancer diagnostics, particularly in aggressive malignancies. A 66-year-old male with a significant smoking history and known chronic obstructive pulmonary disease presented with chronic cough and weight loss. Imaging revealed a central airway mass with mediastinal lymphadenopathy. Bronchoscopic evaluation and biopsy confirmed the diagnosis of metastatic non-small cell lung cancer with high PD-L1 expression. Shortly after the initial procedure, the patient developed airway obstruction due to a rapidly growing endobronchial lesion at the prior biopsy site, confirmed histologically as tumour seeding. Multiple bronchoscopic interventions were required to restore airway patency. Despite prompt escalation to combined chemo-immunotherapy and repeated multimodal airway recanalisation, the disease demonstrated aggressive local recurrence. This case highlights the potential for endobronchial tumour seeding following diagnostic interventions in lung cancer, underscoring the importance of vigilant follow-up and prompt management in cases with rapid disease progression.
活检后肿瘤播散是肺癌诊断中一种罕见但具有临床意义的并发症，尤其是在侵袭性恶性肿瘤中。一名66岁男性，有大量吸烟史且已知患有慢性阻塞性肺疾病，出现慢性咳嗽和体重减轻。影像学检查显示中央气道肿物伴纵隔淋巴结肿大。支气管镜检查及活检确诊为转移性非小细胞肺癌，PD-L1表达高。在初次检查后不久，患者因先前活检部位迅速生长的支气管内病变而出现气道阻塞，组织学证实为肿瘤播散。需要多次支气管镜干预以恢复气道通畅。尽管迅速升级为联合化疗免疫治疗并反复进行多模式气道再通，但疾病仍表现出侵袭性局部复发。该病例突出了肺癌诊断性干预后支气管内肿瘤播散的可能性，强调了对疾病快速进展病例进行密切随访和及时处理的重要性。
