Ahmed Khadija, Rauf Sameer Abdul, Hussain Tooba, Siddiqui Areeba, Ahmed Rubayyi, Khan Najam Ahmed, Shah Hussain Haider, Haque Md Ariful
Dow University of Health Sciences, Karachi, Pakistan.
Liaquat National Medical College, Karachi, Pakistan.
Ann Med Surg (Lond). 2025 Apr 10;87(5):2855-2867. doi: 10.1097/MS9.0000000000003271. eCollection 2025 May.
This comprehensive narrative review thoroughly explores the treatment landscape for achalasia, a rare esophageal motility disorder. Beginning with an introduction outlining the anatomical and clinical aspects of achalasia, the review delves into its historical perspective, tracing the evolution of treatment options from early nonsurgical methods to advanced surgical techniques such as Heller's myotomy and peroral endoscopic myotomy (POEM). Technical perspectives on surgical interventions, including key steps, clinical practice guidelines, and modifications to POEM techniques, are extensively discussed. A comparative analysis between POEM and Heller's myotomy elucidates their indications, contraindications, efficacy, outcomes, and interventions for persistent symptoms or complications. Furthermore, the review explores the adverse events associated with both procedures, highlighting their safety profiles and management strategies. Finally, from a financial perspective, considerations such as operative time, hospital stay length, readmission rates, and quality-adjusted life years are examined, emphasizing the implications for patient decision-making. This review underscores the importance of a multidimensional approach to understanding and managing achalasia, advocating for further research to enhance treatment efficacy and reduce adverse effects.
这篇全面的叙述性综述深入探讨了贲门失弛缓症(一种罕见的食管动力障碍)的治疗现状。综述开篇介绍了贲门失弛缓症的解剖学和临床方面,接着深入探讨其历史背景,追溯了从早期非手术方法到诸如赫勒肌切开术和经口内镜下肌切开术(POEM)等先进手术技术的治疗选择演变。文中广泛讨论了手术干预的技术层面,包括关键步骤、临床实践指南以及POEM技术的改良。POEM与赫勒肌切开术的对比分析阐明了它们的适应证、禁忌证、疗效、结果以及针对持续症状或并发症的干预措施。此外,综述还探讨了与这两种手术相关的不良事件,突出了它们的安全性概况和管理策略。最后,从财务角度审视了诸如手术时间、住院时长、再入院率和质量调整生命年等因素,强调了这些因素对患者决策的影响。本综述强调了采用多维度方法理解和管理贲门失弛缓症的重要性,倡导进一步开展研究以提高治疗效果并减少不良反应。