Bu Yifan, Li Songzhe, Ye Ting, Wang Yuqing, Song Mingrong, Chen Jing
College of Basic Medical and Sciences, Heilongjiang University of Chinese Medicine, Harbin, China.
The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Front Pharmacol. 2025 Apr 23;16:1552801. doi: 10.3389/fphar.2025.1552801. eCollection 2025.
This study aims to elucidate the mitigating effects of the volatile oil of (ATR) on dementia, in order to provide a reference for future research and applications of the volatile oil of ATR in the field of dementia.
A search strategy was developed using terms such as "Acori tatarinowii rhizoma," "Acorus tatarinowii Schott," "Asarone," and "Dementia." The literature search was conducted in PubMed, Web of Science, and Google Scholar, and studies not meeting the inclusion criteria were excluded. This study summarizes the main metabolites, active ingredients, toxicological properties, and pharmacokinetic characteristics of the volatile oil from ATR in mitigating dementia, with a particular focus on its potential mechanisms of action. Furthermore, the study highlights the limitations of existing research and offers insights into future research directions.
The volatile oil of ATR mitigates dementia through multiple pathways, including reducing abnormal protein aggregation, promoting neurogenesis, inhibiting neuronal apoptosis, regulating neurotransmitters, improving synaptic function, modulating autophagy, countering cellular stress, reducing neuroinflammation, and alleviating vascular risk factors.
The multi-pathway pharmacological effects of the volatile oil of ATR are well-aligned with the complex mechanisms of dementia progression, highlighting its significant therapeutic potential for anti-dementia applications. This provides new perspectives for the development of more effective anti-dementia drugs. Nonetheless, further rigorous and high-quality preclinical and clinical investigations are required to address key issues, including the chemical characterization of the volatile oil of ATR, potential synergistic effects among active ingredients, toxicity profiles, and definitive clinical efficacy.
本研究旨在阐明石菖蒲挥发油对痴呆的缓解作用，为石菖蒲挥发油在痴呆领域的未来研究和应用提供参考。
使用“石菖蒲”“石菖蒲属”“细辛醚”和“痴呆”等术语制定检索策略。在PubMed、科学网和谷歌学术上进行文献检索，并排除不符合纳入标准的研究。本研究总结了石菖蒲挥发油在缓解痴呆方面的主要代谢产物、活性成分、毒理学特性和药代动力学特征，特别关注其潜在作用机制。此外，该研究突出了现有研究的局限性，并为未来的研究方向提供了见解。
石菖蒲挥发油通过多种途径缓解痴呆，包括减少异常蛋白质聚集、促进神经发生、抑制神经元凋亡、调节神经递质、改善突触功能、调节自噬、对抗细胞应激、减轻神经炎症和缓解血管危险因素。
石菖蒲挥发油的多途径药理作用与痴呆进展的复杂机制高度契合，突出了其在抗痴呆应用中的显著治疗潜力。这为开发更有效的抗痴呆药物提供了新的视角。尽管如此，仍需要进一步进行严格和高质量的临床前和临床研究，以解决关键问题，包括石菖蒲挥发油的化学表征、活性成分之间的潜在协同作用、毒性概况和确切的临床疗效。
