Wu Jinhui, Feng Siqi, Su Ya, Yi Qijian
Department of Cardiovascular Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Key Laboratory of Children's Important Organ Development and Diseases of Chongqing Municipal Health Commission, National Clinical Research Center for Child Health and Disorders, National Clinical Key Cardiovascular Specialty, Children's Hospital of Chongqing Medical University, Chongqing, China.
Cardiol Young. 2025 May;35(5):1016-1022. doi: 10.1017/S1047951125001829. Epub 2025 May 8.
Kawasaki disease is a leading cause of acquired heart disease in children in the developed world, characterised by acute systemic vasculitis, with a complex aetiology that remains poorly understood. Recent studies have highlighted the potential anti-inflammatory effects of Interleukin-35 in various proinflammatory and cardiovascular conditions. However, the relationship between Interleukin-35 gene polymorphisms and Kawasaki disease susceptibility, particularly in Chinese children, has not been well-explored.In this study, we investigated the association between five Interleukin-35 single-nucleotide polymorphisms-rs2243115, rs2243123, rs583911, rs353698, and rs2302164-and Kawasaki disease in a cohort of Chinese children. A total of ninety-four Kawasaki disease patients and one hundred healthy controls were enrolled, with the Kawasaki disease patients further divided into subgroups based on the presence or absence of coronary artery lesions and incomplete or complete Kawasaki disease. Genotyping of Interleukin-35 polymorphisms was performed using the MassARRAY system.The results showed the GT + GG genotypes and G allele of rs2243115 (T > G) were significantly more prevalent in Kawasaki disease patients with coronary artery lesions than in those without coronary artery lesions, suggesting a possible association with the development of coronary artery lesions. Additionally, the G allele of rs353698 (A > G) was more frequently observed in the incomplete Kawasaki disease group compared to the complete Kawasaki disease group, suggesting a possible association with the risk of incomplete Kawasaki disease.
川崎病是发达国家儿童后天性心脏病的主要病因，其特征为急性全身性血管炎，病因复杂，目前仍了解甚少。最近的研究强调了白细胞介素-35在各种促炎和心血管疾病中的潜在抗炎作用。然而，白细胞介素-35基因多态性与川崎病易感性之间的关系，尤其是在中国儿童中的关系，尚未得到充分研究。在本研究中，我们调查了一组中国儿童中白细胞介素-35的五个单核苷酸多态性（rs2243115、rs2243123、rs583911、rs353698和rs2302164）与川崎病之间的关联。共纳入94例川崎病患者和100例健康对照，川崎病患者根据是否存在冠状动脉病变以及是否为不完全或完全川崎病进一步分为亚组。使用MassARRAY系统对白细胞介素-35多态性进行基因分型。结果显示，rs2243115（T>G）的GT+GG基因型和G等位基因在有冠状动脉病变的川崎病患者中比无冠状动脉病变的患者更为普遍，提示可能与冠状动脉病变的发生有关。此外，与完全川崎病组相比，不完全川崎病组中rs353698（A>G）的G等位基因更常见，提示可能与不完全川崎病的风险有关。
