Lorenzana-Jimenez M, Salas M
Neurobehav Toxicol Teratol. 1985 May-Jun;7(3):215-20.
The effects of neonatal toluene exposure on the development of cortical evoked responses to sciatic nerve and light stimulation, as well as the spontaneous Electrocorticogram (ECoG) of frontal and occipital regions, were studied in rats at different developmental ages. The major findings following the solvent exposure were a significant prolongation in the mean peak latencies of both primary and secondary cortical evoked responses the effects being more severe in the sensorimotor area than in the visual cortical region. Additionally the experimental animals did not show significant differences in the average frequencies histograms of the ECoG in both neocortical areas when compared with control littermates. The data suggest that early toluene exposure was primarily affecting those brain structures underlying locomotor abilities than those related with the functionality of the CNS visual centers.
研究了新生大鼠暴露于甲苯后，在不同发育阶段对坐骨神经和光刺激的皮质诱发反应以及额叶和枕叶区域的自发脑电图（ECoG）发育的影响。溶剂暴露后的主要发现是，初级和次级皮质诱发反应的平均峰值潜伏期显著延长，感觉运动区的影响比视觉皮质区更严重。此外，与对照同窝仔鼠相比，实验动物在两个新皮质区域的ECoG平均频率直方图中没有显示出显著差异。数据表明，早期甲苯暴露主要影响运动能力相关的脑结构，而非与中枢神经系统视觉中心功能相关的脑结构。
