Sergott R C, Brown M J, Polenta R M, Lisak R P, Silberberg D H
Neurology. 1985 Oct;35(10):1438-42. doi: 10.1212/wnl.35.10.1438.
We injected guinea pig optic nerves with serum from patients with MS or acute optic neuritis (ON), or normal subjects. Serum from 12 of 17 MS patients, 3 of 3 patients with ON, and 5 of 11 normal age- and sex-matched controls produced myelin vesiculation and demyelination 24 hours after injection. Nerves injected with demyelinating serum contained oligodendrocytes with pyknotic nuclei and edematous, rarefied cytoplasm. Nerves injected with serum that did not cause demyelination did not have these oligodendrocyte changes. Serum from normal subjects or patients with MS may induce in vivo demyelination in mammalian CNS.
我们将来自多发性硬化症（MS）患者、急性视神经炎（ON）患者或正常受试者的血清注入豚鼠视神经。17例MS患者中的12例、3例ON患者中的3例以及11例年龄和性别匹配的正常对照中的5例的血清在注射后24小时导致了髓鞘囊泡化和脱髓鞘。注射了脱髓鞘血清的神经中含有核固缩的少突胶质细胞以及水肿、稀疏的细胞质。注射未引起脱髓鞘的血清的神经则没有这些少突胶质细胞变化。正常受试者或MS患者的血清可能在哺乳动物中枢神经系统中诱导体内脱髓鞘。
