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Short-term maternal oxytocin administration may protect against poor outcomes of adverse childhood experiences in the offspring.

作者信息

Lax Elad

机构信息

Department of Molecular Biology, Ariel University, Ariel, Israel.

出版信息

Neurotherapeutics. 2025 Jul;22(4):e00605. doi: 10.1016/j.neurot.2025.e00605. Epub 2025 May 7.

DOI:10.1016/j.neurot.2025.e00605
PMID:40340137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12418399/
Abstract
摘要

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Short-term maternal oxytocin administration may protect against poor outcomes of adverse childhood experiences in the offspring.短期内给予母亲催产素可能有助于预防后代不良童年经历带来的不良后果。
Neurotherapeutics. 2025 Jul;22(4):e00605. doi: 10.1016/j.neurot.2025.e00605. Epub 2025 May 7.
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本文引用的文献

1
Maternal oxytocin administration mitigates nociceptive, social, and epigenetic impairments in adolescent offspring exposed to perinatal trauma.给予母体催产素可减轻遭受围产期创伤的青少年后代的伤害感受、社交及表观遗传损伤。
Neurotherapeutics. 2025 Apr 22:e00598. doi: 10.1016/j.neurot.2025.e00598.
2
Exposure to perinatal trauma modifies nociception and gene expression in the prefrontal cortex and hypothalamus of adolescent rats.围产期创伤暴露会改变青春期大鼠前额叶皮质和下丘脑的痛觉感受及基因表达。
J Pain. 2025 Mar;28:104762. doi: 10.1016/j.jpain.2024.104762. Epub 2024 Dec 25.
3
Prevalence of Adverse Childhood Experiences in Child Population Samples: A Systematic Review and Meta-Analysis.儿童群体样本中不良童年经历的患病率：一项系统评价与荟萃分析
JAMA Pediatr. 2025 Jan 1;179(1):19-33. doi: 10.1001/jamapediatrics.2024.4385.
4
Prevalence of Adverse Childhood Experiences Among Adolescents.青少年遭受不良童年经历的情况。
Pediatrics. 2024 Nov 1;154(5). doi: 10.1542/peds.2024-066633.
5
Pathophysiology, blood biomarkers, and functional deficits after intimate partner violence-related brain injury: Insights from emergency department patients and a new rat model.亲密伴侣暴力相关脑损伤后的病理生理学、血液生物标志物及功能缺陷：来自急诊科患者及新型大鼠模型的见解
Brain Behav Immun. 2025 Jan;123:383-396. doi: 10.1016/j.bbi.2024.09.030. Epub 2024 Sep 28.
6
Group differences in OXT methylation between patients with Major Depressive Disorder and healthy controls: A pre-registered replication study.抑郁症患者与健康对照组催产素甲基化的组间差异：一项预先注册的复制研究。
Psychiatry Res. 2024 May;335:115855. doi: 10.1016/j.psychres.2024.115855. Epub 2024 Mar 16.
7
Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy.孕期经历心理困扰的女性的后代的大脑结构和功能结果。
Mol Psychiatry. 2024 Jul;29(7):2223-2240. doi: 10.1038/s41380-024-02449-0. Epub 2024 Feb 28.
8
Anxiety, history of childhood adversity, and experiencing chronic pain in adulthood: A systematic literature review and meta-analysis.焦虑、儿童期逆境史和成年期慢性疼痛：系统文献综述和荟萃分析。
Eur J Pain. 2024 Jul;28(6):867-885. doi: 10.1002/ejp.2232. Epub 2024 Jan 8.
9
Nurture outpaces nature: fostering with an attentive mother alters social dominance in a mouse model of stress sensitivity.后天养育超越先天：有爱心的母亲养育会改变应激敏感性小鼠模型的社会统治地位。
Mol Psychiatry. 2023 Sep;28(9):3816-3828. doi: 10.1038/s41380-023-02273-y. Epub 2023 Oct 16.
10
Anxiety, Depression, and Adverse Childhood Experiences: An Update on Risks and Protective Factors Among Children and Youth.焦虑、抑郁与童年不良经历：儿童和青少年风险与保护因素的最新情况
Acad Pediatr. 2023 May-Jun;23(4):720-721. doi: 10.1016/j.acap.2022.11.013. Epub 2022 Dec 2.