Zhang Guo-Qiong, Zheng Jie, He Lian, Wang Xing-Xing
Department of Reproductive Medicine, Maternal and Child Health Hospital of Hubei Province, Wuhan, China.
Ann Med. 2025 Dec;57(1):2500692. doi: 10.1080/07853890.2025.2500692. Epub 2025 May 9.
To explore the reproductive hormone levels and their correlation in males with abnormal semen liquefaction time, providing evidence-based medical insights for the diagnosis and treatment of abnormal semen liquefaction.
A total of 36 male patients who exhibited a sperm liquefaction time exceeding 60 min in the Maternal and Child Health Hospital of Hubei Province from January 2021 to January 2023 were included. They were classified into the delayed liquefaction group. During the same period, 138 male patients with a sperm liquefaction time of ≤60 min were assigned to a normal liquefaction group. Comparative analysis was performed on reproductive hormone levels between the two groups, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), estradiol (E2), prolactin (PRL), as well as semen parameters such as normal morphology sperm rate, forward motility sperm rate, and sperm concentration. Pearson's correlation analysis was employed to investigate the relationship between reproductive hormones and semen liquefaction time. The effectiveness of biomarkers in predicting delayed semen liquefaction time was assessed using receiver operating characteristic (ROC) curves.
Patients with delayed semen liquefaction had significantly lower rates of normal morphology sperm, forward progressive motility, and sperm concentration when compared to patients with normal liquefaction. Significantly lower FSH, LH, and T levels were observed in patients with delayed semen liquefaction than those with normal liquefaction. Furthermore, a negative correlation was identified between serum FSH and T levels in male infertility patients and semen liquefaction time. The sensitivity of FSH for predicting semen liquefaction defects is 72.2%, whereas testosterone exhibits a sensitivity of 94.4%.
The semen liquefaction time of male infertility patients is closely correlated with semen parameters and reproductive hormone levels. Specifically, FSH and T exhibit a negative correlation with semen liquefaction time.
探讨精液液化时间异常男性的生殖激素水平及其相关性，为精液液化异常的诊断和治疗提供循证医学依据。
纳入2021年1月至2023年1月在湖北省妇幼保健院精液液化时间超过60分钟的36例男性患者，分为液化延迟组。同期选取138例精液液化时间≤60分钟的男性患者作为正常液化组。对两组患者的生殖激素水平进行比较分析，包括促卵泡生成素（FSH）、黄体生成素（LH）、睾酮（T）、雌二醇（E2）、催乳素（PRL），以及精液参数如正常形态精子率、前向运动精子率和精子浓度。采用Pearson相关分析探讨生殖激素与精液液化时间的关系。利用受试者工作特征（ROC）曲线评估生物标志物预测精液液化延迟时间的有效性。
与正常液化患者相比，精液液化延迟患者的正常形态精子率、前向运动率和精子浓度显著降低。精液液化延迟患者的FSH、LH和T水平显著低于正常液化患者。此外，男性不育患者血清FSH和T水平与精液液化时间呈负相关。FSH预测精液液化缺陷的敏感性为72.2%，而睾酮的敏感性为94.4%。
男性不育患者的精液液化时间与精液参数和生殖激素水平密切相关。具体而言，FSH和T与精液液化时间呈负相关。
