与产后机会性细菌入侵相关的流产会降低奶牛的生育能力，并导致生殖激素、血液学指标以及氧化/抗氧化指标紊乱。

Abortion associated with postpartum opportunistic bacterial invasion reduces fertility and induces disturbances of reproductive hormones, hematological profile, and oxidant/antioxidant profiles in dairy cows.

作者信息

Amin Yahia A, Omran Gamal A M, Fouad Samer S, Fawy Mariam A, Ibrahim Rawia M, Khalifa Fatma Ahmed, Ali Rana A

机构信息

Department of Theriogenology, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt.

Department of Microbiology, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Sohag branch, Egypt.

出版信息

J Adv Vet Anim Res. 2023 Dec 31;10(4):654-666. doi: 10.5455/javar.2023.j721. eCollection 2023 Dec.

DOI:10.5455/javar.2023.j721

PMID:38370890

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10868696/

Abstract

OBJECTIVE

The following study examines for the first time the changes that occur in the post-partum period following abortion in the first trimester of dairy cows using hormonal, hematological, and oxidant/antioxidant profiles. In addition, a bacteriological examination was also performed to explore the role of infections in the complications that occur during this period.

MATERIALS AND METHODS

One hundred cows were split into two equal groups: The first group enrolled cows that suffered from abortion in the first trimester. The second group enrolled cows that did not experience abortion problems (the control group). Uterine swabs were collected from cows. Blood samples were collected for hormonal, hematological, and oxidative profiles.

RESULTS

Results reveal that , spp, and spp are the opportunistic bacteria that were isolated from abortive cows with multidrug-resistant (MDR) characteristics. Red blood cell (RBC) count, hemoglobin, mean corpuscular hemoglobin (MCH), and MCH concentration (MCHC) were significantly higher in the abortive group than in controls in the first 3 days after calving. Conversely, total leukocyte count, platelet count, neutrophils, eosinophils, and immunoglobulin G and M were significantly lower in the abortion group than in controls. The concentrations of estradiol, prostaglandin F2α, oxytocin, and cortisol are significantly increased in the abortive cows, while progesterone is significantly decreased. The levels of malondialdehyde (MDA) were higher in the abortive group, while the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) were lower.

CONCLUSION

Abortion during the first trimester of pregnancy increases the risk of postpartum opportunistic bacterial invasion of the uterus. Oxidative stress (OS) and neutropenia are the most important findings that may occur in the postpartum period after abortion and may be due to the abortion itself or its predisposition to opportunistic bacterial invasion of the uterus, which finally causes a fertility reduction.

摘要

目的

以下研究首次使用激素、血液学和氧化/抗氧化指标，考察了奶牛孕早期流产后产后期发生的变化。此外，还进行了细菌学检查，以探究感染在此期间发生的并发症中的作用。

材料与方法

100头奶牛被分为两组，每组数量相等：第一组纳入孕早期流产的奶牛。第二组纳入未出现流产问题的奶牛（对照组）。采集奶牛的子宫拭子。采集血样用于激素、血液学和氧化指标检测。

结果

结果显示，属、属和属是从具有多重耐药（MDR）特征的流产奶牛中分离出的机会致病菌。产犊后的前3天，流产组的红细胞（RBC）计数、血红蛋白、平均红细胞血红蛋白（MCH）和MCH浓度（MCHC）显著高于对照组。相反，流产组的总白细胞计数、血小板计数、中性粒细胞、嗜酸性粒细胞以及免疫球蛋白G和M显著低于对照组。流产奶牛体内雌二醇、前列腺素F2α、催产素和皮质醇的浓度显著升高，而孕酮显著降低。流产组丙二醛（MDA）水平较高，而超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和总抗氧化能力（TAC）水平较低。