继发性跨神经元变性：新生大鼠周围神经切断诱导的皮质变化。

Secondary transneuronal degeneration: cortical changes induced by peripheral nerve section in neonatal rats.

作者信息

Chimelli L, Scaravilli F

出版信息

Neurosci Lett. 1985 Jun 4;57(1):57-63. doi: 10.1016/0304-3940(85)90040-0.

Abstract

Secondary transneuronal degeneration of the cortico-spinal tract (CST) has been induced after sciatic nerve section in newborn rats. Observations made 21-60 days after the lesion showed a considerable decrease in number of myelinated and unmyelinated fibres of the CST ipsilateral to the lesion and of horseradish peroxidase-labelled nerve cells in the somato-sensorimotor cortex of the contralateral cerebral hemisphere. This phenomenon which has never been observed in spite of the frequent studies of experimental peripheral nerve lesions, may be significant in normal and pathological development.

摘要

新生大鼠坐骨神经切断后，可诱发皮质脊髓束（CST）的继发性跨神经元变性。损伤后21 - 60天的观察结果显示，损伤同侧的CST有髓和无髓纤维数量以及对侧大脑半球体感运动皮层中辣根过氧化物酶标记的神经细胞数量均显著减少。尽管对实验性周围神经损伤进行了频繁研究，但这种现象从未被观察到，它可能在正常和病理发育过程中具有重要意义。