头颈部鳞状细胞癌中的三级淋巴结构（综述）

Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review).

作者信息

Hong Shiqin, Wang Qiyue, Yu Dilong, Zheng Juyan, Huang Ping, Gu Jinping, Zhang Yiwen

机构信息

College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, P.R. China.

Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.

出版信息

Oncol Rep. 2025 Jul;54(1). doi: 10.3892/or.2025.8909. Epub 2025 May 9.

DOI:10.3892/or.2025.8909

PMID:40341409

Abstract

The tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) has a critical role in tumor progression and prognosis. The organization of T cells, B cells and high‑endothelial venules into structures termed tertiary lymphoid structures (TLS), are associated with favorable outcomes in HNSCC. Despite their importance, the formation and function of TLS‑associated immune cells in HNSCC have remained elusive. The aim of the present review is to elucidate the mechanism underlying TLS formation, which may contribute to the development of novel and effective immunotherapies for HNSCC, and summarize recent advances in HNSCC treatment.

摘要

头颈部鳞状细胞癌（HNSCC）中的肿瘤微环境在肿瘤进展和预后中起着关键作用。T细胞、B细胞和高内皮微静脉组织形成称为三级淋巴结构（TLS）的结构，与HNSCC的良好预后相关。尽管它们很重要，但HNSCC中与TLS相关的免疫细胞的形成和功能仍不清楚。本综述的目的是阐明TLS形成的潜在机制，这可能有助于开发针对HNSCC的新型有效免疫疗法，并总结HNSCC治疗的最新进展。