Bierich J R
Padiatr Padol. 1985;20(3):249-55.
Nine children with Schwartz-Bartter-syndrome are described. Seven suffered from severe diseases of the CNS, 2 developed the syndrome during treatment with vincristine, the damaging action of which on the CNS is known. The main symptoms of the syndrome are: hyponatremia with consecutive hypotonia of the extracellular space caused by excessive urinary sodium loss. The plasma volume is not diminished. Therapeutically administered NaCl appears in the urine which is hyperosmolar in spite of the hypoosmolarity of the plasma. The increased secretion of ADH which Schwartz et al. postulated to be the cause of the syndrome has been confirmed in recent years. The organism attempts to excrete the increased fluid volume which is retained by ADH, probably by means of a natriuretic hormone, so-called third factor. Enhanced activity of such a factor was assessed in one of our cases.
本文描述了9例施瓦茨-巴特综合征患儿。其中7例患有严重的中枢神经系统疾病，2例在使用长春新碱治疗期间出现该综合征，已知长春新碱对中枢神经系统有损害作用。该综合征的主要症状为：低钠血症，因尿钠过度丢失导致细胞外液相继出现低渗状态。血浆容量未减少。治疗时给予的氯化钠出现在尿液中，尽管血浆呈低渗状态，但尿液却是高渗的。施瓦茨等人推测该综合征的病因是抗利尿激素分泌增加，近年来这一推测已得到证实。机体可能通过一种利钠激素（即所谓的第三因子）来试图排出因抗利尿激素而潴留的增加的液体量。在我们的1例病例中评估了这种因子的活性增强情况。
