Seo Myeong-Seong, Baek Jiyeon, Jeon Myung-Shin
Translational Research Center, Inha University Hospital, Incheon 22332, Korea.
Program in Biomedical Science & Engineering, Inha University, Incheon 22212, Korea.
Immune Netw. 2025 Feb 5;25(2):e1. doi: 10.4110/in.2025.25.e1. eCollection 2025 Apr.
Adult stem cells are a rare population of undifferentiated cells present in almost all body tissues. Depending on their location, stem cells can differentiate into various tissue types, primarily contributing to maintenance, repair, and immune system regulation. Stem cell therapies have significant potential in regenerative medicine and treatment of inflammatory diseases. However, many factors must be considered for successful clinical commercialization, including enhancing therapeutic potential, ensuring product differentiation, and optimizing the manufacturing process for large-scale production. The development of sophisticated regulatory mechanisms may enhance therapeutic applications. The aryl hydrocarbon receptor (AhR) is expressed in all adult stem cells, and its activation and function are tightly regulated. Understanding the role and regulation of AhR is crucial for developing effective stem cell therapies. This review examines the role of the AhR in regulating the fundamental characteristics of adult stem cells, which may contribute to advancing adult stem cell therapies.
成体干细胞是几乎存在于所有身体组织中的一类罕见的未分化细胞。根据其所在位置，干细胞可分化为各种组织类型，主要有助于维持、修复和免疫系统调节。干细胞疗法在再生医学和炎症性疾病治疗方面具有巨大潜力。然而，要实现成功的临床商业化，必须考虑许多因素，包括增强治疗潜力、确保产品差异化以及优化大规模生产的制造工艺。复杂监管机制的发展可能会增强治疗应用。芳烃受体（AhR）在所有成体干细胞中均有表达，其激活和功能受到严格调控。了解AhR的作用和调控对于开发有效的干细胞疗法至关重要。本综述探讨了AhR在调节成体干细胞基本特性方面的作用，这可能有助于推进成体干细胞疗法。
