Korotkov Alexander, Myznikov Artem, Komarova Anastasia, Isaeva Elena, Solnyshkina Irina, Cherednichenko Denis, Didur Michael, Kireev Maxim
Interdisciplinary Brain Research Department, N.P. Bechtereva Institute of Human Brain Russian Academy of Science, Saint Petersburg, Russia.
Department of General and Clinical Psychology, The Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.
Depress Anxiety. 2025 May 1;2025:2617054. doi: 10.1155/da/2617054. eCollection 2025.
Currently, translation into clinical practice of scientific knowledge on pathological reorganization of brain mechanisms in psychiatric disorders, as suggested by functional neuroimaging data, remains limited. This situation calls for the exploration of new approaches, which were recently proposed for the combined use of the simultaneous application of psychodiagnostic testing and fMRI scanning. Consequently, a self-rated psychodiagnostic scale was used as an experimental task during fMRI scanning for patients with major depressive disorder. Given the promising neuroimaging results obtained in these studies, in current research, our objective was to replicate these results and conduct an fMRI study using statements from the von Zerssen depression as experimental conditions. Eighteen patients with recurrent depressive disorder and healthy volunteers participated in the study to replicate the group size of previous research. The results obtained showed that patients with recurrent depressive disorder exhibited greater activity in the right precuneus and bilateral supramarginal gyrus than healthy controls while responding to diagnostically specific (DS) statements compared to diagnostically neutral (DN) ones. These findings replicate the main results of the original study and emphasize the potential of this approach in the field of translational psychiatry. In addition, they contribute to understanding the pathophysiological mechanisms of depression through the use of this unique fMRI paradigm.
目前，正如功能神经影像学数据所显示的，关于精神疾病中脑机制病理重组的科学知识转化为临床实践的程度仍然有限。这种情况需要探索新的方法，最近有人提出将心理诊断测试和功能磁共振成像扫描同时应用相结合。因此，在对重度抑郁症患者进行功能磁共振成像扫描时，使用了一种自评心理诊断量表作为实验任务。鉴于这些研究中获得的有前景的神经影像学结果，在当前的研究中，我们的目标是重复这些结果，并使用冯·泽尔森抑郁量表中的陈述作为实验条件进行功能磁共振成像研究。18名复发性抑郁症患者和健康志愿者参与了该研究，以重复先前研究的样本量。所得结果表明，与健康对照组相比，复发性抑郁症患者在对诊断特异性（DS）陈述而非诊断中性（DN）陈述做出反应时，右侧楔前叶和双侧缘上回的活动更强。这些发现重复了原始研究的主要结果，并强调了这种方法在转化精神病学领域的潜力。此外，它们通过使用这种独特的功能磁共振成像范式，有助于理解抑郁症的病理生理机制。
