Saadh Mohamed J, Allela Omer Qutaiba B, Abdul Kareem Radhwan, Sanghvi Gaurav, PadmaPriya G, Thakur Rishabh, Kumari Mukesh, Gupta Sofia, Khaitov Kakhramon, Sameer Hayder Naji, Yaseen Ahmed, Athab Zainab H, Adil Mohaned
Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
College of Pharmacy, Alnoor University, Nineveh, Iraq.
Iran J Basic Med Sci. 2025;28(6):680-690. doi: 10.22038/ijbms.2025.85335.18442.
Psoriasis is a long-lasting inflammatory skin condition that impacts millions globally. The occurrence of this disorder differs significantly across various areas, resulting from a complex interplay of genetic and environmental influences. In psoriasis, the pathogenesis represents a complex interaction of innate and adaptive immunity that plays a significant role in the disease manifestation process. Many genetic factors predispose to psoriasis, which is considered a polygenic disease. Several genes concerning pathways like NF-κB and PI3K/Akt that modulate the amplification of inflammatory response and keratinocyte dysregulation have been elaborated in the light of their differential expression, susceptibility loci, and polymorphisms. Such genetic insights could open a whole new avenue for precision medicine in which biomarkers and gene-targeting therapies are promising options for personalized treatment. This review emphasizes the need for complex investigations into psoriasis, from molecular mechanisms to clinical manifestations, to bridge the gap between basic research and therapeutic development by furthering the understanding of psoriasis and paving the way for innovative treatments addressing skin lesions and systemic effects.
银屑病是一种持久的炎症性皮肤病，全球有数百万人受其影响。这种疾病在不同地区的发病率差异显著，是遗传和环境因素复杂相互作用的结果。在银屑病中，发病机制表现为先天性免疫和适应性免疫的复杂相互作用，在疾病表现过程中起重要作用。许多遗传因素易导致银屑病，该病被认为是一种多基因疾病。鉴于一些与NF-κB和PI3K/Akt等通路相关的基因在炎症反应放大和角质形成细胞失调调节方面的差异表达、易感基因座和多态性，对这些基因进行了阐述。此类遗传学见解可为精准医学开辟全新途径，其中生物标志物和基因靶向疗法是个性化治疗的有前景的选择。本综述强调有必要对银屑病进行全面研究，从分子机制到临床表现，通过加深对银屑病的理解并为解决皮肤病变和全身影响的创新治疗铺平道路，来弥合基础研究与治疗开发之间的差距。
