Ikemachi Ryosuke, Tomita Yusuke, Otani Yoshihiro, Ishida Joji, Fujii Kentaro, Higaki Fumiyo, Ono Sawako, Kanemura Yonehiro, Tanaka Shota
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Department of Neurosurgery and Neuroendovascular Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Hiroshima, Japan.
NMC Case Rep J. 2025 Apr 11;12:153-158. doi: 10.2176/jns-nmc.2024-0306. eCollection 2025.
We report a case of adult-onset gangliocytoma in the parietal lobe. A 54-year-old woman presented with sensory disturbance in her right upper limb. A computed tomography scan revealed a cystic and calcified lesion in the left parietal lobe. She underwent a left parietal craniotomy with gross total resection, and the pathological diagnosis was confirmed as gangliocytoma. Gangliocytomas are very rare tumors of the central nervous system, predominantly affecting children and young adults, and are often located in the temporal lobe. Reports of gangliocytomas developing after middle age are uncommon. To assess the epidemiology of gangliocytoma, we utilized data from the Surveillance, Epidemiology, and End Results database. From January 1, 2000, to December 31, 2021, a total of 74 cases were identified, 18 of which were in patients over 50 years of age. While 27 patients had tumors in the temporal lobe, the most frequent site, others had tumors in different locations. Notably, there were no patients over 50 with gangliocytoma in the parietal lobe in the Surveillance, Epidemiology, and End Results registry. These findings suggest that in older patients, although gangliocytomas located outside the temporal lobe are rare, they are kept in mind as one of the differential diagnoses.
我们报告一例顶叶成人起病的神经节细胞瘤。一名54岁女性出现右上肢感觉障碍。计算机断层扫描显示左顶叶有一个囊性和钙化病变。她接受了左顶叶开颅手术并进行了肿瘤全切除，病理诊断确诊为神经节细胞瘤。神经节细胞瘤是中枢神经系统非常罕见的肿瘤，主要影响儿童和年轻人，且常位于颞叶。中年后发生神经节细胞瘤的报道并不常见。为评估神经节细胞瘤的流行病学情况，我们利用了监测、流行病学和最终结果数据库的数据。从2000年1月1日至2021年12月31日，共识别出74例病例，其中18例患者年龄超过50岁。虽然27例患者的肿瘤位于最常见的部位颞叶，但其他患者的肿瘤位于不同部位。值得注意的是，在监测、流行病学和最终结果登记处中，没有50岁以上的患者顶叶患有神经节细胞瘤。这些发现表明，在老年患者中，虽然位于颞叶以外的神经节细胞瘤很少见，但应将其作为鉴别诊断之一予以考虑。
