Paffenholz Pia
Klinik und Poliklinik für Urologie, Uro-Onkologie, Roboter-assistierte und Spezielle Urologische Chirurgie, Universitätsklinikum Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
Urologie. 2025 May 9. doi: 10.1007/s00120-025-02601-w.
Testicular tumors are rare in childhood but differ significantly from adult forms in terms of etiology, histology, and prognosis. Early diagnosis and appropriate treatment are crucial for the prognosis and quality of life of affected children.
The aim of this article is to provide an overview of the etiology, classification, clinical presentation, diagnostic tests, and treatment of pediatric testicular tumors.
This article is based on an analysis of current literature.
Pediatric testicular tumors are benign in 60-75% of cases, most commonly teratomas or Leydig cell tumors. Malignant tumors such as yolk sac tumors are rare and show low metastatic potential. Diagnostics include ultrasound, tumor markers (AFP, hCG, LDH), and imaging (MRI, CT). Treatment consists of organ-sparing surgery in suspected benign cases and orchiectomy in malignant cases. Chemotherapy is reserved for metastatic tumors. In localized stage I disease, surveillance is often sufficient.
Pediatric germ cell tumors differ from adult testicular tumors in terms of incidence, malignancy, and histology. Treatment decisions should always be made within an interdisciplinary framework.
睾丸肿瘤在儿童期较为罕见,但在病因、组织学和预后方面与成人形式有显著差异。早期诊断和适当治疗对于患病儿童的预后和生活质量至关重要。
本文旨在概述小儿睾丸肿瘤的病因、分类、临床表现、诊断测试和治疗方法。
本文基于对当前文献的分析。
小儿睾丸肿瘤60% - 75%为良性,最常见的是畸胎瘤或Leydig细胞瘤。卵黄囊瘤等恶性肿瘤罕见且转移潜能低。诊断方法包括超声、肿瘤标志物(甲胎蛋白、人绒毛膜促性腺激素、乳酸脱氢酶)和影像学检查(磁共振成像、计算机断层扫描)。治疗方法包括对疑似良性病例进行保留器官手术,对恶性病例进行睾丸切除术。化疗仅用于转移性肿瘤。对于局部I期疾病,通常进行监测就足够了。
小儿生殖细胞肿瘤在发病率、恶性程度和组织学方面与成人睾丸肿瘤不同。治疗决策应始终在多学科框架内做出。