具有超螺旋诱导十字形结构的共价闭合DNA的解链转变

Melting transition of covalently closed DNA with supercoil-induced cruciforms.

作者信息

Majumdar R, Thakur A R

出版信息

Nucleic Acids Res. 1985 Aug 26;13(16):5883-93. doi: 10.1093/nar/13.16.5883.

DOI:10.1093/nar/13.16.5883

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC321919/

Abstract

The melting curve for covalently closed supercoiled DNA has been studied by assuming the existence of cruciforms as significant structural perturbations in the pre-melting region. The statistical mechanical treatment used incorporates these cruciform structures through an appropriate sequence generating function. The variation of the effective hydrogen bond energy with temperature is taken into account by an empirical procedure. The results obtained are in close agreement with the corresponding experimental data in TEA solution where the effect of heterogeneity of the base pairs is minimized.

摘要

通过假设十字形结构作为熔解前区域中重要的结构扰动的存在，研究了共价闭合超螺旋DNA的熔解曲线。所采用的统计力学处理方法通过适当的序列生成函数纳入了这些十字形结构。通过经验程序考虑了有效氢键能量随温度的变化。在TEA溶液中，碱基对异质性的影响最小化，所获得的结果与相应的实验数据密切吻合。

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引用本文的文献

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