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MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4.

作者信息

Mishima Eikan, O'Neill Thomas J, Hoefig Kai P, Chen Deng, Behrens Gesine, Henkelmann Bernhard, Ito Junya, Nakagawa Kiyotaka, Heissmeyer Vigo, Conrad Marcus, Krappmann Daniel

机构信息

Institute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg 85764, Germany.

Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.

出版信息

Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2507997122. doi: 10.1073/pnas.2507997122. Epub 2025 May 9.

DOI:10.1073/pnas.2507997122
PMID:40343971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12107143/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf6b/12107143/d1225b8f921e/pnas.2507997122fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf6b/12107143/76f716b571c4/pnas.2507997122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf6b/12107143/d1225b8f921e/pnas.2507997122fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf6b/12107143/76f716b571c4/pnas.2507997122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf6b/12107143/d1225b8f921e/pnas.2507997122fig02.jpg

相似文献

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MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4.MALT1抑制剂MI-2通过直接靶向谷胱甘肽过氧化物酶4（GPX4）诱导铁死亡。
Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2507997122. doi: 10.1073/pnas.2507997122. Epub 2025 May 9.
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Inhibition of MALT1 reduces ferroptosis in rat hearts following ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway.抑制 MALT1 通过增强 Nrf2/SLC7A11 通路减少大鼠心脏缺血/再灌注后的铁死亡。
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引用本文的文献

1
Reply to Mishima et al.: MALT1 modulates GPX4 expression by regulating its stability.对三岛等人的回复：MALT1 通过调节 GPX4 的稳定性来调控其表达。
Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2508813122. doi: 10.1073/pnas.2508813122. Epub 2025 May 9.

本文引用的文献

1
Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.解析MALT1-RC3H1轴在调节谷胱甘肽过氧化物酶4（GPX4）蛋白稳定性中的作用。
Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2419625121. doi: 10.1073/pnas.2419625121. Epub 2024 Dec 31.
2
Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells.胎牛血清中硒含量对培养细胞中铁死亡易感性和硒蛋白表达的影响。
J Toxicol Sci. 2024;49(12):555-563. doi: 10.2131/jts.49.555.
3
A tangible method to assess native ferroptosis suppressor activity.
一种评估内源性铁死亡抑制剂活性的切实可行的方法。
Cell Rep Methods. 2024 Mar 25;4(3):100710. doi: 10.1016/j.crmeth.2024.100710. Epub 2024 Feb 24.
4
Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells.MALT1（黏膜相关淋巴组织淋巴瘤易位蛋白1）的药理学抑制作用可诱导血管平滑肌细胞发生铁死亡。
Cell Death Discov. 2023 Dec 15;9(1):456. doi: 10.1038/s41420-023-01748-9.
5
HOIP modulates the stability of GPx4 by linear ubiquitination.HOIP 通过线性泛素化调节 GPx4 的稳定性。
Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2214227119. doi: 10.1073/pnas.2214227119. Epub 2022 Oct 24.
6
Optimization of the Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.通过降低代谢和提高全血中的效力来优化吡唑并嘧啶 MALT1 蛋白酶抑制剂的效力。
J Med Chem. 2020 Dec 10;63(23):14594-14608. doi: 10.1021/acs.jmedchem.0c01246. Epub 2020 Nov 20.
7
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.谷胱甘肽过氧化物酶 4（GPX4）利用硒来预防过氧化氢诱导的铁死亡。
Cell. 2018 Jan 25;172(3):409-422.e21. doi: 10.1016/j.cell.2017.11.048. Epub 2017 Dec 28.
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MALT1 Inhibition Is Efficacious in Both Naïve and Ibrutinib-Resistant Chronic Lymphocytic Leukemia.MALT1抑制在初治和依鲁替尼耐药的慢性淋巴细胞白血病中均有效。
Cancer Res. 2017 Dec 15;77(24):7038-7048. doi: 10.1158/0008-5472.CAN-17-2485. Epub 2017 Oct 9.
9
Development of new Malt1 inhibitors and probes.新型Malt1抑制剂和探针的开发。
Bioorg Med Chem. 2016 Aug 1;24(15):3312-29. doi: 10.1016/j.bmc.2016.03.035. Epub 2016 Mar 28.
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MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.MALT1 小分子抑制剂在体外和体内特异性抑制 ABC-DLBCL。
Cancer Cell. 2012 Dec 11;22(6):812-24. doi: 10.1016/j.ccr.2012.11.003.