Raue F, Minne H, Schäfer D, Ziegler R
MMW Munch Med Wochenschr. 1977 Feb 18;119(7):219-24.
The significance of measuring calcitonin by biological and radioimmunological methods for diagnostic and therapeutic purposes is demonstrated in 18 cases of medullary thyroid carcinoma (MTC). The radioimmunoassay used permits the differentiation between normals (up to 0.5 ng/ml) and patients with MTC (3 to 120 ng/ml). As clinical symptomatology is often unspecific (tumor of the neck, perhaps in combination with diarrhea), the determination of calcitonin proved to be a useful preoperative diagnostic tool which can be improved by calcitonin stimulation tests (pentagastrin i.v.). Calcitonin values provide information on the completeness of surgical procedures or the recurrence of the tumor before clinical symptoms are manifest.
通过生物学和放射免疫方法测量降钙素用于诊断和治疗目的的意义，在18例甲状腺髓样癌（MTC）中得到了证实。所采用的放射免疫测定法能够区分正常人群（降钙素水平高达0.5纳克/毫升）和MTC患者（降钙素水平为3至120纳克/毫升）。由于临床症状通常不具有特异性（颈部肿物，可能伴有腹泻），降钙素测定被证明是一种有用的术前诊断工具，通过降钙素刺激试验（静脉注射五肽胃泌素）可使其更加完善。在临床症状出现之前，降钙素值能为手术操作的完整性或肿瘤复发提供信息。
