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耳部透明质酸注射后因血管变异导致的永久性视力丧失:两例病例报告及文献综述

Permanent Vision Loss Due to Vascular Variation After Ear Hyaluronic Acid Injection: Two Case Reports and Literature Reviews.

作者信息

Huang Lei, Luo Song-Tao, Xie Guang-Hui, Fu Xue, Ye Zhen-Wei, He Qing-Yun, Tan Bo-Wen, Lu Jin-Qiang, Li Shen-Hong, Liao Xuan, Liu Hong-Wei, Jiang Xiao

机构信息

Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Huangpu West Road 613, Guangzhou, Guangdong, 510630, People's Republic of China.

Innovative Technology Research Institute of Tissue Repair and Regeneration, Key Laboratory of Regenerative Medicine, Ministry of Education, Huangpu West Road 613, Guangzhou, Guangdong, 510630, People's Republic of China.

出版信息

Aesthetic Plast Surg. 2025 Jul;49(14):3968-3975. doi: 10.1007/s00266-025-04881-1. Epub 2025 May 9.

Abstract

BACKGROUND

In line with modern aesthetic principles, a prominent and voluminous auricle is considered to enhance facial structure by making it appear smaller and more refined. Recently, there has been a growing trend toward using injectable treatments as an alternative to traditional surgical procedures for correcting lying ears. This shift has led to an increase in reported complications associated with these interventions.

OBJECTS

This report aims to investigate the mechanisms leading to vision loss following hyaluronic acid (HA) injections in the ear and to propose preventive measures and countermeasures.

METHOD

We present two rare cases of blindness following HA injections into the ears. The first patient experienced vision loss in both eyes, while the second suffered unilateral blindness in the left eye. In both cases, local hyaluronidase injections were promptly administered. Ophthalmological evaluations revealed central retinal artery occlusion, followed by arterial thrombolysis treatments performed 3 and 6 h post-diagnosis, respectively. Postoperative management included daily interventions to reduce intraocular pressure, promote vasodilation, enhance nerve nourishment, and provide hyperbaric oxygen therapy.

RESULTS

Digital subtraction angiography revealed structural variations in the ophthalmic arteries of both patients, which we hypothesize to be the primary cause of their blindness. In Case 1, the bilateral ophthalmic arteries and, in Case 2, the left ophthalmic artery were found to primarily originate from the external carotid artery. After treatment, Patient 1 exhibited a detectable index in the right eye, whereas the left eye was limited to light perception. Patient 2 showed recovery, with only defects in the inferior quadrant of the left eye.

CONCLUSION

The administration of filler injections in the auricular region is considered a high-risk aesthetic procedure due to the dense network of blood vessels and nerves, and significant anatomical variations. The use of large volumes of HA in this confined space can compress vascular structures and nerves, potentially leading to visual impairment. Therefore, ear filler injections are not recommended as a routinely substitute for the surgical correction of lying ears.

LEVEL OF EVIDENCE IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .

摘要

背景

根据现代美学原则,突出且丰满的耳廓被认为可通过使面部显得更小、更精致来增强面部结构。最近,使用注射治疗作为矫正招风耳的传统手术方法的替代方案的趋势日益增长。这种转变导致与这些干预相关的并发症报告有所增加。

目的

本报告旨在研究透明质酸(HA)耳部注射后导致视力丧失的机制,并提出预防措施和应对策略。

方法

我们报告两例罕见的HA耳部注射后失明病例。第一例患者双眼视力丧失,第二例患者左眼单眼失明。在这两例病例中,均立即进行了局部透明质酸酶注射。眼科评估显示为视网膜中央动脉阻塞,分别在诊断后3小时和6小时进行了动脉溶栓治疗。术后管理包括每日降低眼压、促进血管舒张、增强神经滋养以及提供高压氧治疗的干预措施。

结果

数字减影血管造影显示两名患者的眼动脉均存在结构变异,我们推测这是其失明的主要原因。在病例1中,双侧眼动脉,在病例2中,左眼动脉主要起源于颈外动脉。治疗后,患者1右眼有可检测指标,而左眼仅存光感。患者2显示恢复,仅左眼下方象限有缺陷。

结论

由于耳部血管和神经网络密集以及显著的解剖变异,在耳廓区域进行填充剂注射被认为是一种高风险的美容手术。在这个有限空间内使用大量HA会压迫血管结构和神经,可能导致视力损害。因此,不建议将耳部填充剂注射作为矫正招风耳的常规替代手术。

证据等级IV:本刊要求作者为每篇文章指定证据等级。有关这些循证医学评级的完整描述,请参阅目录或作者在线指南 www.springer.com/00266

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