含环糊精复合物的栓剂。第2部分：溶出度与吸收研究。
Suppositories containing cyclodextrin complexes. Part 2: Dissolution and absorption studies.
作者信息
Szente L, Apostol I, Gerlóczy A, Szejtli J
出版信息
Pharmazie. 1985 Jun;40(6):406-7.
PMID:4034649
Abstract
The dissolution and absorption of poorly water-soluble drugs from rectal suppositories can be enhanced by complexing these substances (e.g., essential oils, indomethacin) with beta-cyclodextrin. Preliminary in vivo studies showed, that the application of cyclodextrin complexes to suppositories, the same as to oral applications, resulted in an increased blood level.
摘要
通过将难溶性药物（如精油、吲哚美辛）与β-环糊精络合，可以提高其从直肠栓剂中的溶解和吸收。初步的体内研究表明，将环糊精络合物应用于栓剂，与口服给药一样，会使血液水平升高。
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