大鼠空回肠旁路术的厌恶后果：一项条件性味觉厌恶分析。
Aversive consequences of jejunoileal bypass in the rat: a conditioned taste aversion analysis.
作者信息
Sclafani A, Kramer T H, Koopmans H S
出版信息
Physiol Behav. 1985 May;34(5):709-19. doi: 10.1016/0031-9384(85)90369-5.
Jejunoileal bypass (JIB) surgery reduces food intake and body weight in obese humans and rats. Human bypass patients report visceral discomfort following surgery, and the present study assessed the aversive consequences of JIB in rats using a conditioned taste aversion paradigm. In Experiment 1 rats given a cherry-flavored solution immediately after JIB surgery subsequently displayed a strong aversion to the cherry flavor compared to Bypass and Sham-Bypass control groups. Rats in Experiment 2 were familiarized with cherry solution prior to surgery and they did not display an aversion to the solution after receiving a JIB. In Experiment 3, Bypass rats who developed a cherry flavor aversion after JIB subsequently lost this aversion following reconnection of their intestinal tract. The rats in Experiment 4 displayed an aversion to a saccharin-flavored chow that was eaten shortly after JIB surgery, although the aversion was not as pronounced as that obtained with the cherry solution. The results suggest that JIB produces a persisting malaise in rats that may contribute to the feeding and weight inhibitory effects of the operation.
空肠回肠旁路术（JIB）手术可减少肥胖人类和大鼠的食物摄入量及体重。接受旁路手术的人类患者术后会出现内脏不适，本研究使用条件性味觉厌恶范式评估了JIB手术对大鼠的厌恶后果。在实验1中，JIB手术后立即给予樱桃味溶液的大鼠，与旁路手术对照组和假旁路手术对照组相比，随后对樱桃味表现出强烈的厌恶。实验2中的大鼠在手术前熟悉了樱桃溶液，接受JIB手术后它们并未对该溶液表现出厌恶。在实验3中，JIB手术后对樱桃味产生厌恶的旁路手术大鼠，在肠道重新连接后，随后失去了这种厌恶。实验4中的大鼠对JIB手术后不久食用的甜味素味食物表现出厌恶，尽管这种厌恶不如对樱桃溶液的厌恶那么明显。结果表明，JIB手术在大鼠中产生了持续的不适，这可能有助于该手术对进食和体重的抑制作用。
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