Arasaki Rei, Inoue Tatsuya, Terasaki Hiroko, Ueno Shinji, Tsunoda Kazushige, Takeuchi Jun, Kitahata Shohei, Yanagi Yasuo, Maruyama-Inoue Maiko, Kadonosono Kazuaki
Department of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Aichi, Japan.
Doc Ophthalmol. 2025 May 10. doi: 10.1007/s10633-025-10024-3.
To evaluate subjective and objective macular retinal function and morphology in eyes after autologous retinal transplantation (ART).
We conducted the study in three patients with large macular holes (MHs) who underwent ART. The examination modalities included optical coherence tomography (OCT), microperimetry (MP-3), and focal macular electroretinography (FMERG) with 10-degree and 5-degree stimulus spots under infrared camera monitoring centered on the treated MHs after ART.
All three patients showed improved visual acuity after the ART; MP-3 showed relatively good sensitivity around the fixation point with a dense scotoma at the center of the graft. All MHs were closed with autologous grafts and the size of MHs was decreased. OCT revealed clearly visible ellipsoid zones of the host retina around the grafted retina, however one transplanted eye showed disorganized outer layer of the host retina near the border of graft-host retina. FMERGs with the 10-degree stimulus were recorded successfully in all three treated eyes with more than half of a- and b-wave amplitudes of the fellow eyes. FMERGs with the 5-degree stimulus were recorded successfully in two of the treated and their fellow eyes.
The FMERGs showed well-maintained macular retinal function after ART. The electrophysiologic and anatomic outcomes suggested that the host retina around the transplanted retina may play an important role in the postoperative macular retinal function with the mechanical support by the graft.
评估自体视网膜移植（ART）术后眼睛黄斑区视网膜的主观和客观功能及形态。
我们对3例接受ART的黄斑大裂孔（MH）患者进行了研究。检查方式包括光学相干断层扫描（OCT）、微视野计（MP-3）以及在ART术后以治疗的MH为中心，在红外摄像机监测下，用10度和5度刺激光斑进行的黄斑局灶视网膜电图（FMERG）检查。
所有3例患者在ART术后视力均有提高；MP-3显示在注视点周围敏感性相对较好，移植片中心有浓密暗点。所有MH均通过自体移植片封闭，MH大小减小。OCT显示移植视网膜周围宿主视网膜的椭圆体带清晰可见，然而，一只移植眼在移植-宿主视网膜边界附近的宿主视网膜外层结构紊乱。所有3只治疗眼均成功记录到10度刺激的FMERG，其a波和b波振幅超过对侧眼的一半。2只治疗眼及其对侧眼成功记录到5度刺激的FMERG。
FMERG显示ART术后黄斑区视网膜功能维持良好。电生理和解剖学结果表明，移植视网膜周围的宿主视网膜在术后黄斑区视网膜功能中可能通过移植片的机械支撑发挥重要作用。
