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一名来自印度南部儿童的神经类黑色素沉着病:诊断与治疗见解

Neuromelioidosis in a child from Southern India: Diagnostic and therapeutic insights.

作者信息

U Pratibha Bhat, Ashraf Asem Ali, Roy Anulekha

机构信息

Nitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Department of Microbiology, Mangalore, Karnataka, India.

出版信息

Diagn Microbiol Infect Dis. 2025 Sep;113(1):116885. doi: 10.1016/j.diagmicrobio.2025.116885. Epub 2025 May 2.

Abstract

Melioidosis, caused by Burkholderia pseudomallei, presents with diverse clinical manifestations. This is a case of a 1-year-old female presenting with fever, and altered sensorium. Her MRI had revealed features suggestive of brainstem encephalitis. Cerebrospinal fluid analysis confirmed the presence of Burkholderia pseudomallei. Treatment involved a two-phase antibiotic therapy: the acute phase and the eradication phase, and after 14 days of appropriate antibiotics, the patient stabilized and was discharged with follow-up care. This case underscores the importance of recognizing the rare neurological presentation of neuromelioidosis in pediatric patients, emphasizing the need for timely diagnosis and treatment to improve outcomes.

摘要

类鼻疽病由类鼻疽伯克霍尔德菌引起,临床表现多样。这是一例1岁女性患者,表现为发热和意识改变。其磁共振成像(MRI)显示有脑干脑炎的特征。脑脊液分析证实存在类鼻疽伯克霍尔德菌。治疗采用两阶段抗生素疗法:急性期和根除期,在使用适当抗生素治疗14天后,患者病情稳定并出院接受随访护理。该病例强调了认识小儿神经类鼻疽病这种罕见神经表现的重要性,突出了及时诊断和治疗以改善预后的必要性。

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