Api A M, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Friedrich A, Burton G A, Cancellieri M A, Chon H, Cronin M, Crotty S, Dagli M L, Dekant W, Deodhar C, Farrell K, Fryer A D, Jones L, Joshi K, Lapczynski A, Laskin D L, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning T M, Piersma A H, Ritacco G, Sadekar N, Schember I, Schultz T W, Siddiqi F, Sipes I G, Sullivan G, Thakkar Y
Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
Member Expert Panel for Fragrance Safety, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
Food Chem Toxicol. 2025 Jul;201 Suppl 1:115524. doi: 10.1016/j.fct.2025.115524. Epub 2025 May 8.
2-(Methylpropyl)quinoline was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 2-isobutylquinoline (CAS # 93-19-6) show that 2-(methylpropyl)quinoline is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 2-(methylpropyl)quinoline is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). Data from read-across analog quinoline (CAS # 91-22-5) show that there are no safety concerns for 2-(methylpropyl)quinoline for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 2-(methylpropyl)quinoline is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; 2-(methylpropyl)quinoline was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
对2-（甲基丙基）喹啉进行了遗传毒性、重复剂量毒性、生殖毒性、局部呼吸道毒性、光刺激性/光致敏性、皮肤致敏性和环境安全性评估。来自交叉参照类似物2-异丁基喹啉（CAS编号93-19-6）的数据表明，预计2-（甲基丙基）喹啉无遗传毒性。使用毒理学关注阈值（TTC）对Cramer III类物质的重复剂量、生殖和局部呼吸道毒性终点进行了评估，2-（甲基丙基）喹啉的暴露量低于TTC（分别为0.0015毫克/千克/天、0.0015毫克/千克/天和0.47毫克/天）。来自交叉参照类似物喹啉（CAS编号91-22-5）的数据表明，在当前申报的使用水平下，2-（甲基丙基）喹啉不存在皮肤致敏的安全问题。基于紫外/可见（UV/Vis）光谱对光刺激性/光致敏性终点进行了评估；预计2-（甲基丙基）喹啉无光刺激性/光致敏性。对环境终点进行了评估；根据国际香精协会（IFRA）环境标准，2-（甲基丙基）喹啉被认定为非持久性、生物累积性和毒性（PBT）物质，基于其在欧洲和北美的当前使用量（VoU）计算的风险商数（即预测环境浓度/预测无效应浓度[PEC/PNEC]）<1。
