Ramesh Rashmi, Rekha N D, Gopal Shubha
Department of Studies in Microbiology, University of Mysore, Manasagangotri, Mysuru, Karnataka, India.
Department of Biotechnology, JSS College of Arts, Commerce and Science (Autonomous), Mysuru, Karnataka, India.
Arch Microbiol. 2025 May 10;207(6):141. doi: 10.1007/s00203-025-04346-8.
Pseudomonas aeruginosa is an opportunistic human pathogenic bacterium that is a common cause of both acute and chronic infections. Multidrug-resistant P. aeruginosa poses a significant challenge to antibiotics and therapeutic approaches due to its pathogenicity, virulence, and biofilm-forming ability mediated by quorum sensing. Understanding the pathogenic mechanisms is essential for developing potential drug targets. In this regard, strategies aimed at combating the targeted inhibition of virulence, quorum sensing pathways, secretion systems, biofilm-associated two-component systems, and signalling system regulators (such as c-di-GMP) associated with biofilm formation are critical. Several new antimicrobial agents have been developed using these strategies, including antimicrobial peptides, bacteriophages, nanoantibiotics, photodynamics, and natural products, which are considered promising therapeutic tools. In this review, we address the concept of biofilms, their regulation, and recent treatment strategies to target P. aeruginosa, a clinically significant pathogen known for biofilm formation.
铜绿假单胞菌是一种机会性人类病原菌，是急性和慢性感染的常见病因。多重耐药的铜绿假单胞菌因其致病性、毒力以及由群体感应介导的生物膜形成能力，对抗生素和治疗方法构成了重大挑战。了解其致病机制对于开发潜在的药物靶点至关重要。在这方面，旨在对抗与生物膜形成相关的毒力、群体感应途径、分泌系统、生物膜相关双组分系统以及信号系统调节剂（如环二鸟苷酸）的靶向抑制策略至关重要。利用这些策略已经开发出了几种新型抗菌剂，包括抗菌肽、噬菌体、纳米抗生素、光动力疗法和天然产物，它们被认为是有前景的治疗工具。在本综述中，我们阐述了生物膜的概念、其调控以及针对铜绿假单胞菌的最新治疗策略，铜绿假单胞菌是一种以形成生物膜而闻名的具有临床意义的病原体。
