共济失调毛细血管扩张症细胞通过掺入溴脱氧尿苷或碘脱氧尿苷表现出与正常人细胞相同的放射增敏反应。
Ataxia telangiectasia cells exhibit the same radiosensitization response by incorporation of BrdUrd or IdUrd as do normal human cells.
作者信息
Raaphorst G P, Azzam E I, Vadasz J A
出版信息
Radiat Res. 1985 Sep;103(3):455-60.
Normal and ataxia telangiectasia (AT) human cells were exposed to 10(-5) mole/liter bromodeoxyuridine (BrdUrd) or iododeoxyuridine (IdUrd). High-pressure liquid chromatography (HPLC) measurements showed that up to 26 and 23% of the thymidine in DNA was substituted by BrdUrd in normal and AT cells, respectively. The incorporation of BrdUrd or IdUrd into DNA resulted in radiosensitization in normal and AT cells. When exposed to equal concentrations of BrdUrd and IdUrd, the BrdUrd caused greater radiosensitization than IdUrd in both normal and AT cells.
将正常人和患有共济失调毛细血管扩张症（AT）的人的细胞暴露于10⁻⁵摩尔/升的溴脱氧尿苷（BrdUrd）或碘脱氧尿苷（IdUrd）中。高压液相色谱（HPLC）测量结果表明，在正常细胞和AT细胞中，DNA中的胸腺嘧啶核苷分别有高达26%和23%被BrdUrd取代。BrdUrd或IdUrd掺入DNA会导致正常细胞和AT细胞产生放射增敏作用。当暴露于同等浓度的BrdUrd和IdUrd时，在正常细胞和AT细胞中，BrdUrd引起的放射增敏作用都比IdUrd更强。
Zotero 插件