Guetterman Heather M, Crider Krista S, Fothergill Amy, Bose Beena, Johnson Christina B, Jabbar Shameem, Zhang Mindy, Pfeiffer Christine M, Rose Charles E, Qi Yan Ping, Williams Jennifer L, Mehta Saurabh, Kuriyan Rebecca, Finkelstein Julia L
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Clin Nutr ESPEN. 2025 Aug;68:176-188. doi: 10.1016/j.clnesp.2025.05.011. Epub 2025 May 9.
In clinical populations, vitamin B deficiency has been associated with adverse metabolic health (e.g., gestational diabetes). Population-level data among women of reproductive age could inform screening and interventions. The objective of this analysis was to examine the prevalence of adverse metabolic characteristics (elevated adiposity and central adiposity, hypertension, elevated glycated hemoglobin [HbA1c]) and associations of vitamin B status with metabolic characteristics in women as part of a population-based biomarker survey in Southern India.
Participants (n = 980 women 15-40 y; not pregnant or lactating) were assessed for total vitamin B, holotranscobalamin, methylmalonic acid, homocysteine, and HbA1c. Categorical anthropometry assessments and bioelectrical impedance analysis (e.g., whole body (WF%) and trunk (TF%) fat) were assessed among adults (≥18 y). Linear and binomial regressions were used to examine associations of vitamin B status with metabolic characteristics.
Overall, 25 % of participants had HbA1c ≥5.7 % (HbA1c ≥5.7-<6.5 %: 20.0 %; ≥6.5 %: 5.0 %), and 18.6 % had hypertension (Stage 1: 16.4 %; Stage 2: 2.2 %). Among adults, 23.4 % had body mass index of (BMI) 25.0-<30.0 kg/m, 9.6 % had BMI ≥30.0 kg/m, 13.4 % had elevated waist circumference (WC; >88.9 cm), and 20.8 % had elevated waist-hip ratio (WHR; ≥0.85 cm). Overall, higher vitamin B concentrations were associated with lower BMI and WC. Among adults, higher vitamin B concentrations were associated with lower WF% and TF%; and lower prevalence of overweight (BMI ≥25.0 kg/m) and elevated WC, WHR, and WF%. Similarly, vitamin B <148 pmol/L was associated with higher BMI and WC overall and, among adults, higher WF% and TF%, and increased overweight (BMI ≥25.0 kg/m; prevalence ratio: 1.31; 95 % confidence interval: 1.09-1.58), and elevated WC (>88.9 cm; 1.85 [1.32-2.60]), WHR (≥85.0; 1.38 [1.07-1.78]), WF% (>35 %; 1.29 [1.10-1.51]), and TF% (>35 %; 1.25 [1.06-1.49]).
The burden of adverse metabolic characteristics was substantial in this population of young, apparently healthy women. Among those with vitamin B <148 pmol/L there was increased central adiposity and overweight status. Evaluating vitamin B and metabolic outcomes prospectively could inform screening and interventions to improve women's health.
NCT04048330.
在临床人群中，维生素B缺乏与不良代谢健康状况（如妊娠期糖尿病）相关。育龄女性的人群水平数据可为筛查和干预提供参考。本分析的目的是在印度南部一项基于人群的生物标志物调查中，研究不良代谢特征（肥胖和中心性肥胖、高血压、糖化血红蛋白[HbA1c]升高）的患病率，以及维生素B状态与女性代谢特征之间的关联。
对参与者（n = 980名15 - 40岁女性；非妊娠或哺乳期）进行总维生素B、全转钴胺素、甲基丙二酸、同型半胱氨酸和HbA1c的评估。对成年人（≥18岁）进行分类人体测量评估和生物电阻抗分析（如全身脂肪百分比[WF%]和躯干脂肪百分比[TF%]）。采用线性回归和二项式回归研究维生素B状态与代谢特征之间的关联。
总体而言，25%的参与者HbA1c≥5.7%（HbA1c≥5.7 - <6.5%：20.0%；≥6.5%：5.0%），18.6%患有高血压（1期：16.4%；2期：2.2%）。在成年人中，23.4%的人体质量指数（BMI）为25.0 - <30.0 kg/m，9.6%的人BMI≥30.0 kg/m，13.4%的人腰围（WC）升高（>88.9 cm），20.8%的人腰臀比（WHR）升高（≥~0.85 cm）。总体而言，较高的维生素B浓度与较低的BMI和WC相关。在成年人中，较高的维生素B浓度与较低的WF%和TF%相关；超重（BMI≥25.0 kg/m）、WC、WHR和WF%升高的患病率较低。同样，维生素B<148 pmol/L与总体上较高的BMI和WC相关，在成年人中与较高的WF%和TF%相关，超重（BMI≥25.0 kg/m；患病率比：1.31；95%置信区间：1.09 - 1.58）、WC升高（>88.9 cm；1.85 [1.32 - 2.60]）、WHR（≥85.0；1.38 [1.07 - 1.78]）、WF%（>35%；1.29 [1.10 - 1.51]）和TF%（>35%；1.25 [1.06 - 1.49]）增加相关。
在这群年轻、看似健康的女性中，不良代谢特征的负担很重。在维生素B<148 pmol/L的人群中，中心性肥胖和超重状况增加。前瞻性评估维生素B和代谢结果可为改善女性健康的筛查及干预提供参考。
NCT04048330
