Rawlings N C, Hyland J H
Prostaglandins. 1985 Jun;29(6):933-51. doi: 10.1016/0090-6980(85)90219-9.
Concentrations of prostaglandins E and F (PGE and PGF) were measured in the embryo or fetus, extra embryonic or fetal membranes (membranes), intercaruncular and caruncular endometrium and plasma collected from uterine and ovarian arterial and venous vessels from separate groups of ewes laparotomized at 5 day intervals from day 10 to day 55 of pregnancy. Our purpose was to investigate the role of prostaglandins E and F in the maternal recognition of pregnancy, implantation and early placental function. Our data suggest that the initial maintenance of the corpus luteum in the pregnant ewe does not involve a reduction in PGF production, compared to pregnant ewes; but a change in the pattern of PGF secretion. This is accompanied by an elevation in PGE production of similar magnitude to that observed in non pregnant ewes. The extra embryonic/fetal membranes appear to be the major source of elevated PGF levels in the maternal circulation prior to day 30 of pregnancy. Between days 35 and 55 of gestation the rising PGF levels in maternal serum probably come from the fetus. Over the same period PGE levels rise in the fetus and intercaruncular endometrium, but PGE secretion into the maternal circulation is not enhanced. A role for PGF and PGE in fetal, placental and uterine growth is suggested; placental and uterine endocrine function may also be targets.
从妊娠第10天到第55天，每隔5天对单独分组的母羊进行剖腹手术，收集胚胎或胎儿、胎膜（胎膜）、子宫肉阜间和肉阜处的子宫内膜以及从子宫和卵巢动静脉采集的血浆中的前列腺素E和F（PGE和PGF）浓度。我们的目的是研究前列腺素E和F在母体妊娠识别、着床和早期胎盘功能中的作用。我们的数据表明，与妊娠母羊相比，妊娠母羊黄体的最初维持并不涉及PGF产生的减少，而是PGF分泌模式的改变。与此同时，PGE的产生量升高，幅度与未妊娠母羊相似。在妊娠第30天之前，胎膜似乎是母体循环中PGF水平升高的主要来源。在妊娠第35天至55天期间，母血清中PGF水平的升高可能来自胎儿。在同一时期，胎儿和子宫肉阜间子宫内膜中的PGE水平升高，但进入母体循环的PGE分泌并未增强。提示PGF和PGE在胎儿、胎盘和子宫生长中起作用；胎盘和子宫内分泌功能也可能是作用靶点。
