Gröhn Y
Res Vet Sci. 1985 Jul;39(1):24-8.
Propionate utilisation by the liver in spontaneously ketotic dairy cows was investigated by determining blood glucose levels after an intravenous sodium propionate load (2.5 mmol kg-1). In addition, blood ketone body concentrations were measured after propionate loading. Cows were divided into three groups (control, mildly ketotic and severely ketotic) by their blood acetoacetate concentrations. Plasma glucose concentrations increased significantly after sodium propionate injection in all three groups (P less than 0.05). The maximum glucose concentration occurred earlier in the control group than in the ketotic groups. Changes in glucose concentrations following propionate loading of control and ketotic cows differed significantly at 20 minutes and beyond. Differences in the change in glucose concentration between mildly ketotic and severely ketotic cows were not significant. Acetoacetate concentration was significantly decreased at five minutes and beyond after the injection in ketotic cows, whereas beta-hydroxybutyrate concentration decreased more slowly. A decrease in beta-hydroxybutyrate concentration was significant at 40 minutes and beyond in the severely ketotic group and at 10 minutes and beyond in the mildly ketotic group after loading.
通过静脉注射丙酸钠负荷（2.5 mmol kg-1）后测定血糖水平，研究了自发酮血症奶牛肝脏对丙酸盐的利用情况。此外，在丙酸盐负荷后测量血酮体浓度。根据血乙酰乙酸浓度将奶牛分为三组（对照组、轻度酮血症组和重度酮血症组）。所有三组在注射丙酸钠后血浆葡萄糖浓度均显著升高（P小于0.05）。对照组的最大葡萄糖浓度出现时间早于酮血症组。在20分钟及之后，对照组和酮血症组奶牛在丙酸盐负荷后葡萄糖浓度的变化有显著差异。轻度酮血症奶牛和重度酮血症奶牛之间葡萄糖浓度变化的差异不显著。酮血症奶牛在注射后5分钟及之后乙酰乙酸浓度显著降低，而β-羟基丁酸浓度下降较慢。负荷后，重度酮血症组在40分钟及之后β-羟基丁酸浓度下降显著，轻度酮血症组在10分钟及之后下降显著。
