Babeliowsky Wietske A, Swinnen Bart, Hoogland Jeroen, de Bie Rob M A, van Rootselaar Anne-Fleur
Department of Clinical Neurophysiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Tremor Other Hyperkinet Mov (N Y). 2025 May 7;15:22. doi: 10.5334/tohm.1008. eCollection 2025.
Orthostatic tremor (OT) is characterized by a lower extremity tremor causing unsteadiness while standing, urging patients to lean, walk, or sit to ease symptoms. This severely disrupts daily life and reduces quality of life (QoL), though the extent of QoL impairment remains largely unknown. The objective of this cohort study was to evaluate the effect of OT on daily functioning and well-being over time.
In this prospective single-center and community based cohort study, OT patients annually completed self-report scales from 2018 to 2024, including the Dutch OT-questionnaire, Hospital Anxiety and Depression Scale (HADS), (instrumental) Activities of Daily Living, and the Short Form-36 (SF-36) to evaluate QoL.
Fifty-three OT patients participated in the study. OT patients showed reduced well-being compared to the general population based on outcomes from the SF-36 and HADS, with 30 out of 53 patients experiencing potential or suspected depression and/or anxiety. Despite viewing OT as progressive, most patients saw no significant changes in overall well-being or daily functioning, although a significant difference was found between baseline and last follow-up for physical role limitation.
Although OT patients report reduced well-being, both daily functioning and overall well-being remained stable over time, despite progressive symptoms. This is likely due to patients increased ability to adapt to OT symptoms. Additionally, a substantial portion had potential or suspected depression or anxiety.
Orthostatic tremor (OT) patients report reduced quality of life, with worsened walking ability and increased weather sensitivity over time. Despite this, daily functioning and overall well-being remained stable throughout the study. A significant portion of patients also showed potential or suspected depression and/or anxiety.
直立性震颤（OT）的特征是下肢震颤，导致站立时不稳，促使患者倚靠、行走或坐下以缓解症状。这严重扰乱了日常生活并降低了生活质量（QoL），尽管生活质量受损的程度在很大程度上仍不清楚。这项队列研究的目的是评估OT随时间推移对日常功能和幸福感的影响。
在这项前瞻性单中心社区队列研究中，OT患者在2018年至2024年期间每年完成自我报告量表，包括荷兰OT问卷、医院焦虑抑郁量表（HADS）、（工具性）日常生活活动量表和简短健康调查问卷（SF-36）以评估生活质量。
53名OT患者参与了该研究。根据SF-36和HADS的结果，与一般人群相比，OT患者的幸福感降低，53名患者中有30名经历了潜在或疑似抑郁和/或焦虑。尽管认为OT是进行性的，但大多数患者的整体幸福感或日常功能没有显著变化，尽管在身体角色限制方面基线和最后一次随访之间存在显著差异。
尽管OT患者报告幸福感降低，但尽管症状逐渐加重，日常功能和整体幸福感随时间仍保持稳定。这可能是由于患者适应OT症状的能力增强。此外，相当一部分患者有潜在或疑似抑郁或焦虑。
直立性震颤（OT）患者报告生活质量下降，随着时间推移步行能力恶化且对天气的敏感性增加。尽管如此，在整个研究过程中日常功能和整体幸福感保持稳定。相当一部分患者还表现出潜在或疑似抑郁和/或焦虑。
