Gallo Lucas, Kim Patrick, Gallo Matteo, Olaiya Oluwatobi, Main Cheryl, Avram Ronen, Bain James, Thoma Achilles, Voineskos Sophocles H, Coroneos Christopher
Department of Surgery, Division of Plastic Surgery, McMaster University, Hamilton, ON, Canada.
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Plast Surg (Oakv). 2025 May;33(2):269-275. doi: 10.1177/22925503231214760. Epub 2023 Nov 22.
Microbial colonization of burn wounds leads to infection, which is a major cause of morbidity/mortality, prolonged admission, and cost. This study aims to investigate the incidence of positive burn wound colonization and its associated risk factors in a provincial referral center within a single-payer system. We performed a retrospective review of all adult (≥18 years) patients admitted to a single, tertiary burn center, with a primary burn diagnosis between January 2011 and 2021. Microbiology records were screened to identify patients with culture-positive burn wounds. Univariable and multivariable logistic regression analyses were used to evaluate risk factors associated with burn site colonization. The sample included = 634 participants. Most were male (72.1%), with a flame injury (62%), and had a mean age of 47.6 (±18.0) years and a TBSA of 13.5% (±14.8). The incidence of positive burn wound colonization was 27.3%. Increasing participant age, diabetic status, larger burn TBSA, presence of full-thickness burns, inhalation injury, and lower limb and trunk involvement were associated with statistically significant ( ≤ .05) increased odds of a positive burn wound culture. This study provides an estimate of the incidence of primary burn wound colonization at a single, tertiary care, burn center as well as identifies potential risk factors associated with this outcome. Clinicians should consider closely monitoring patients with these risk factors for possible progression to clinical burn site infection. Future research should address strategies to mitigate colonization in patients with identified risk factors.
烧伤创面的微生物定植会导致感染，这是发病/死亡、住院时间延长和成本增加的主要原因。本研究旨在调查单一支付系统下省级转诊中心烧伤创面定植阳性的发生率及其相关危险因素。我们对2011年1月至2021年期间入住一家三级烧伤中心、主要诊断为烧伤的所有成年（≥18岁）患者进行了回顾性研究。筛查微生物学记录以确定烧伤创面培养阳性的患者。采用单变量和多变量逻辑回归分析来评估与烧伤部位定植相关的危险因素。样本包括634名参与者。大多数为男性（72.1%），因火焰烧伤（62%），平均年龄为47.6（±18.0）岁，总体表面积（TBSA）为13.5%（±14.8）。烧伤创面定植阳性的发生率为27.3%。参与者年龄增加、糖尿病状态、更大的烧伤TBSA、存在全层烧伤、吸入性损伤以及下肢和躯干受累与烧伤创面培养阳性的几率增加具有统计学意义（≤.05）。本研究提供了一家三级烧伤中心原发性烧伤创面定植的发生率估计，并确定了与该结果相关的潜在危险因素。临床医生应密切监测具有这些危险因素的患者，以防其可能进展为临床烧伤创面感染。未来的研究应探讨减轻具有已确定危险因素患者定植的策略。
