Slimani Imane, Safini Fatima, Miry Achraf, Abbaoui Sanae, Amaoui Bouchra
Radiation Therapy, Souss-Massa University Hospital, Agadir, MAR.
Radiation Therapy, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, MAR.
Cureus. 2025 Apr 9;17(4):e81932. doi: 10.7759/cureus.81932. eCollection 2025 Apr.
Ovarian metastases from squamous cell carcinoma of the uterine cervix are extremely rare. We present the case of a 57-year-old patient who was followed for stage IVA cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO), initially treated with concurrent chemoradiation. Two years after complete remission, she developed bilateral ovarian metastases, which were incidentally discovered and confirmed by histopathological and immunohistochemical analysis. This case represents the first description of ovarian metastases following irradiation of a locally advanced cervical cancer. The occurrence of ovarian metastases in this context, where the ovaries had been irradiated, raises questions about tumor biology and treatment resistance.
子宫颈鳞状细胞癌的卵巢转移极为罕见。我们报告一例57岁患者，根据国际妇产科联盟（FIGO）分期为IVA期宫颈癌，最初接受同步放化疗。完全缓解两年后，她出现双侧卵巢转移，这是偶然发现并经组织病理学和免疫组化分析证实的。该病例是局部晚期宫颈癌放疗后卵巢转移的首次描述。在卵巢已接受放疗的情况下发生卵巢转移，引发了关于肿瘤生物学和治疗耐药性的问题。
