Dehzad Mohammad Jafar, Raja Ali, Moghdani Zahra, Sohrabi Zahra, Fararooei Mohammad, Famouri Mandana, Askarpour Moein, Babajafari Siavash
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz 7153675500, Iran.
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz 7153675500, Iran.
Prev Nutr Food Sci. 2025 Apr 30;30(2):120-131. doi: 10.3746/pnf.2025.30.2.120.
Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder that requires effective dietary strategies for management. In this randomized, double-blind, placebo-controlled clinical trial, the effects of low-fat yogurt enriched with konjac glucomannan (KGM) and inulin on glycemic control, lipid profiles, anthropometric indices, and oxidative stress were investigated in patients with T2DM. Eighty participants were randomly assigned to consume either 150 g of yogurt enriched with 1.5 g of KGM and 1.5 g of inulin (n=40) or plain low-fat yogurt (n=40) daily for 8 weeks. The primary outcomes were fasting blood glucose and fasting insulin levels, insulin sensitivity indices [homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)], and glycated hemoglobin. Secondary outcomes included lipid profile [total cholesterol (TC), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride (TG)], anthropometric indices (weight, body mass index, fat mass, skeletal muscle, and waist circumference), and oxidative stress markers. Compared to control group, the intervention significantly improved fasting insulin levels (-1.85 µIU/mL, =0.042), HOMA-IR (-0.89, =0.029), and QUICKI (0.11, =0.032). Lipid profile analysis revealed reductions in TC (-18.51 mg/dL, =0.049) and TG levels (-15.0 mg/dL, =0.041). These findings suggest that daily consumption of yogurt fortified with KGM and inulin significantly enhances insulin sensitivity and lipid profiles in patients with T2DM over an 8-week period. This dietary intervention shows promise as a complementary strategy for T2DM management. Further studies are needed to assess the long-term outcomes, optimize doses, and elucidate the underlying mechanisms of this intervention.
2型糖尿病（T2DM）是一种常见的代谢紊乱疾病，需要有效的饮食策略来进行管理。在这项随机、双盲、安慰剂对照的临床试验中，研究了富含魔芋葡甘露聚糖（KGM）和菊粉的低脂酸奶对T2DM患者血糖控制、血脂谱、人体测量指标和氧化应激的影响。80名参与者被随机分配，每天食用150克富含1.5克KGM和1.5克菊粉的酸奶（n = 40）或普通低脂酸奶（n = 40），持续8周。主要结局指标为空腹血糖和空腹胰岛素水平、胰岛素敏感性指数[胰岛素抵抗稳态模型评估（HOMA-IR）和定量胰岛素敏感性检查指数（QUICKI）]以及糖化血红蛋白。次要结局指标包括血脂谱[总胆固醇（TC）、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯（TG）]、人体测量指标（体重、体重指数、脂肪量、骨骼肌和腰围）以及氧化应激标志物。与对照组相比，干预组显著改善了空腹胰岛素水平（-1.85 μIU/mL，P = 0.042）、HOMA-IR（-0.89，P = 0.029）和QUICKI（0.11，P = 0.032）。血脂谱分析显示TC水平降低（-18.51 mg/dL，P = 0.049），TG水平降低（-15.0 mg/dL，P = 0.041）。这些发现表明，在8周的时间里，每天食用添加KGM和菊粉的酸奶可显著提高T2DM患者的胰岛素敏感性和改善血脂谱。这种饮食干预作为T2DM管理的一种补充策略显示出前景。需要进一步研究来评估长期结局、优化剂量并阐明这种干预的潜在机制。
