维生素D强化低脂酸奶对糖尿病绝经后女性血糖状况、人体测量指标、炎症及骨转换的影响：一项随机对照临床试验

Effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women: A randomised controlled clinical trial.

作者信息

Jafari Tina, Faghihimani Elham, Feizi Awat, Iraj Bijan, Javanmard Shaghayegh Haghjooy, Esmaillzadeh Ahmad, Fallah Aziz A, Askari Gholamreza

机构信息

Food Security Research Center and Department of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Clin Nutr. 2016 Feb;35(1):67-76. doi: 10.1016/j.clnu.2015.02.014. Epub 2015 Mar 5.

DOI:10.1016/j.clnu.2015.02.014

PMID:25794439

Abstract

BACKGROUND & AIMS: Low levels of serum 25-hydroxy vitamin D (25(OH)D) are common in type 2 diabetic patients and cause several complications particularly, in postmenopausal women due to their senile and physiological conditions. This study aimed to assess the effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women.

METHODS

In a randomized, placebo-controlled, double-blind parallel-group clinical trial, 59 postmenopausal women with type 2 diabetes received fortified yogurt (FY; 2000 IU vitamin D in 100 g/day) or plain yogurt (PY) for 12 weeks. Glycemic markers, anthropometric indexes, inflammatory, and bone turnover markers were assessed at baseline and after 12 weeks.

RESULTS

After intervention, in FY group (vs PY group), were observed: significant increase in serum 25(OH)D and decrease of PTH (stable values in PY); significant improvement in serum fasting insulin, HOMA-IR, HOMA-B, QUICKI, and no changes in serum fasting glucose and HbA1c (significant worsening of all indexes in PY); significant improvement in WC, WHR, FM, and no change in weight and BMI (stable values in PY); significant increase of omentin (stable in PY) and decrease of sNTX (significant increase in PY). Final values of glycemic markers (except HbA1c), omentin, and bone turnover markers significantly improved in FY group compared to PY group. Regarding final values of serum 25(OH)D in FY group, subjects were classified in insufficient and sufficient categories. Glycemic status improved more significantly in the insufficient rather than sufficient category; whereas the other parameters had more amelioration in the sufficient category.

CONCLUSIONS

Daily consumption of 2000 IU vitamin D-fortified yogurt for 12 weeks improved glycemic markers (except HbA1c), anthropometric indexes, inflammation, and bone turnover markers in postmenopausal women with type 2 diabetes.

TRIAL REGISTRATION

www.irct.ir (IRCT2013110515294N1).

摘要

背景与目的

2型糖尿病患者血清25-羟维生素D（25(OH)D）水平较低很常见，尤其在绝经后女性中，由于她们的衰老和生理状况，会引发多种并发症。本研究旨在评估维生素D强化低脂酸奶对糖尿病绝经后女性血糖状态、人体测量指标、炎症和骨转换的影响。

方法

在一项随机、安慰剂对照、双盲平行组临床试验中，59名绝经后2型糖尿病女性接受强化酸奶（FY；100克/天含2000国际单位维生素D）或普通酸奶（PY），为期12周。在基线和12周后评估血糖标志物、人体测量指标、炎症和骨转换标志物。

结果

干预后，与PY组相比，FY组观察到：血清25(OH)D显著升高，甲状旁腺激素降低（PY组为稳定值）；血清空腹胰岛素、HOMA-IR、HOMA-B、QUICKI显著改善，血清空腹血糖和糖化血红蛋白无变化（PY组所有指标显著恶化）；腰围、腰臀比、脂肪量显著改善，体重和体重指数无变化（PY组为稳定值）；网膜素显著增加（PY组稳定），骨特异性I型胶原交联C末端肽降低（PY组显著增加）。与PY组相比，FY组血糖标志物（糖化血红蛋白除外）、网膜素和骨转换标志物的最终值显著改善。关于FY组血清25(OH)D的最终值，受试者被分为不足和充足类别。血糖状态在不足类别中改善更为显著，而其他参数在充足类别中改善更为明显。