Sheng Aizhu, Zhang Lili, Zhu Darong, Hu Guangzhu, Shi Xiaobei, Zong Qianqian, Wang Pengli, Wang Zhen
Department of Radiology, Ningbo No. 2 hospital, Ningbo, Zhejiang, 315000, People's Republic of China.
Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310029, People's Republic of China.
Int J Gen Med. 2025 May 5;18:2439-2447. doi: 10.2147/IJGM.S508938. eCollection 2025.
To analyze the clinical value of coronary CT angiography (CCTA) for evaluating aortic stiffness and elasticity in patients with angina and non-obstructive coronary artery (ANOCA).
The case data of 120 patients who were diagnosed with ANOCA and underwent CCTA in our hospital were collected and set as the case group, and 86 healthy subjects who underwent medical check-up and ANOCA testing in our hospital during the same period were set as the control group. The differences in CCTA indices of ascending aortic stiffness and aortic elasticity, left ventricular function indices of left ventricular ejection fraction (LVEF) and cardiac output (CO) were compared between the two groups.
The arterial compliance (AC) and arterial distensibility (AD) values in the case group were significantly lower than those in the control group, while arterial stiffness (β) value was significantly higher in the case group compared to the control group (P<0.05). The LVEF and CO values of patients in the case group were significantly lower than those in the control group (P<0.05). The CCTA indices AC and AD of patients in the case group exhibited a significant positive correlation with their LVEF (r=0.133, r=0.062, P<0.05), while β showed a negative correlation with LVEF (r=-0.092, P=0.005).
Aortic stiffness and elasticity in CCTA indices of ANOCA patients exhibited significant alterations, and the correlation analysis suggested a correlation of CCTA aortic stiffness and elasticity indices with left ventricular performance indices.
分析冠状动脉CT血管造影（CCTA）评估心绞痛和非阻塞性冠状动脉疾病（ANOCA）患者主动脉僵硬度和弹性的临床价值。
收集我院120例诊断为ANOCA并接受CCTA检查的患者的病例资料作为病例组，同期选取86例在我院进行体检且接受ANOCA检测的健康受试者作为对照组。比较两组升主动脉僵硬度和主动脉弹性的CCTA指标、左心室射血分数（LVEF）和心输出量（CO）等左心室功能指标的差异。
病例组的动脉顺应性（AC）和动脉扩张性（AD）值显著低于对照组，而病例组的动脉僵硬度（β）值显著高于对照组（P<0.05）。病例组患者的LVEF和CO值显著低于对照组（P<0.05）。病例组患者的CCTA指标AC和AD与其LVEF呈显著正相关（r=0.133，r=0.062，P<0.05），而β与LVEF呈负相关（r=-0.092，P=0.005）。
ANOCA患者CCTA指标中的主动脉僵硬度和弹性表现出显著改变，相关性分析表明CCTA主动脉僵硬度和弹性指标与左心室功能指标相关。
