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反应性关节炎

Reactive Arthritis.

作者信息

António Santos Carolina, Trigueiros Frederico, Machado Leite Inês

机构信息

Serviço Medicina de Interna, Unidade Local de Saúde Santa Maria, Lisbon, Portugal.

Associação Protectora dos Diabéticos de Portugal (APDP), Lisbon, Portugal.

出版信息

Eur J Case Rep Intern Med. 2025 Apr 4;12(5):005350. doi: 10.12890/2025_005350. eCollection 2025.

Abstract

UNLABELLED

Reactive arthritis is a form of seronegative spondylarthritis that presents following an infection, with clear associations to specific microorganisms. It is a rare entity and typically affects young adults. An 88-year-old woman, admitted in our ward with pseudomembranous enterocolitis and acute renal lesion, presented with axial oligoarthritis on the 11 day after onset of symptoms. It was accompanied by elevation of inflammatory parameters - positive HLA-B27 and seronegative to rheumatoid factor, and anti-cyclic citrullinated peptide. The patient improved following treatment with non-steroidal anti-inflammatory drugs and inflammatory parameters normalised, with no recurrence after one year on follow-up. This case illustrates a rare entity in the elderly, with an established association in more recent years with .

LEARNING POINTS

Post-infectious disease syndromes are poorly understood, and their management relies on their distinct pathophysiologies.Reactive arthritis can occur days or weeks after a gastrointestinal or urogenital bacterial infection and can present as Reiter's syndrome. The diagnosis is clinical, and its treatment should consider prevention, effective treatment of the causative agent and should target inflammation.We present a case of reactive arthritis that was diagnosed in an elderly patient (less common) with a trigger bacterium that has been implicated more and more consistently in recent years.

摘要

未标注

反应性关节炎是一种血清阴性脊柱关节炎,在感染后出现,与特定微生物有明确关联。它是一种罕见疾病,通常影响年轻成年人。一名88岁女性因伪膜性小肠结肠炎和急性肾损伤入住我们病房,在症状出现后第11天出现中轴寡关节炎。伴有炎症指标升高——HLA - B27阳性,类风湿因子及抗环瓜氨酸肽抗体阴性。患者经非甾体抗炎药治疗后病情改善,炎症指标恢复正常,随访一年无复发。该病例说明了老年人中的一种罕见疾病,近年来已明确与……有关联。

学习要点

感染后疾病综合征了解甚少,其管理依赖于各自不同的病理生理学。反应性关节炎可在胃肠道或泌尿生殖道细菌感染数天或数周后发生,可表现为赖特综合征。诊断依靠临床,其治疗应考虑预防、有效治疗病原体且应以炎症为靶点。我们报告一例在老年患者(较不常见)中诊断出的反应性关节炎病例,其触发细菌近年来越来越多地被认为与之相关。

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本文引用的文献

1
Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens.
Curr Rheumatol Rep. 2021 Jul 1;23(7):53. doi: 10.1007/s11926-021-01018-6.
2
A case of reactive arthritis due to Clostridium difficile colitis.
J Community Hosp Intern Med Perspect. 2016 Feb 17;6(1):30151. doi: 10.3402/jchimp.v6.30151. eCollection 2016.
3
Diagnosis and classification of reactive arthritis.
Autoimmun Rev. 2014 Apr-May;13(4-5):546-9. doi: 10.1016/j.autrev.2014.01.005. Epub 2014 Jan 10.
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Reiter's syndrome: the classic triad and more.
J Am Acad Dermatol. 2008 Jul;59(1):113-21. doi: 10.1016/j.jaad.2008.02.047. Epub 2008 Apr 23.

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