Dewilde Sarah, Qi Cynthia Z, De Ruyck Femke, Paci Sandra, Van de Veire Lucas, Griffiths Alison, Wolfe Gil I, Mantegazza Renato, Phillips Glenn
Services in Health Economics, Brussels, Belgium.
argenx, Boston, MA, United States.
Front Public Health. 2025 Apr 25;13:1538789. doi: 10.3389/fpubh.2025.1538789. eCollection 2025.
Myasthenia Gravis (MG) is a debilitating autoimmune disorder associated with fatigue and weakness in the ocular, respiratory, bulbar and limb muscles. This study evaluates productivity losses for MG patients and their caregivers by MG symptom severity.
In the multinational MyRealWorld-MG study, 1,049 MG patients and caregivers reported on work productivity (sick leave, reduced working hours, early retirement). Productivity losses were calculated using the average wage per hour. A UK perspective was adopted for the whole sample, and country-specific analyses were conducted for Italy, Spain and the US. The MG-Activities of Daily Living (MG-ADL) score was used to estimate the association between symptom severity and productivity losses, with patients categorized as having mild (0-4), moderate (5-9), or severe (> = 10) symptoms.
In the MyRealWorld-MG study, 36.5% of MG patients reported taking sick leave within the last month and 11.4% reported stopping work (or retiring early) due to MG. Furthermore, 36.0% required caregiver support with 14.6% of caregivers reducing working hours and 13.4% stopping work. Mean productivity losses were £16,630/year for patients and caregivers combined, largely attributable to patient productivity losses (£13,891). Patients with severe MG incurred 3.8 times more productivity losses compared to patients with mild disease. Productivity loss estimates varied between Italy, Spain and the US.
The impact of MG on patients' and caregivers' work productivity leads many of them to reduce work hours or retire early, resulting in significant productivity losses. The magnitude of these productivity losses is correlated with symptom severity and varies by country.
重症肌无力（MG）是一种使人衰弱的自身免疫性疾病，与眼部、呼吸、延髓和肢体肌肉的疲劳及无力有关。本研究按MG症状严重程度评估MG患者及其照料者的生产力损失。
在多国开展的MyRealWorld-MG研究中，1049名MG患者及其照料者报告了工作生产力情况（病假、工作时长减少、提前退休）。生产力损失通过每小时平均工资计算得出。对整个样本采用英国视角，并对意大利、西班牙和美国进行了国别分析。使用MG日常生活活动（MG-ADL）评分来估计症状严重程度与生产力损失之间的关联，患者被分为症状轻微（0-4）、中度（5-9）或重度（≥10）。
在MyRealWorld-MG研究中，36.5%的MG患者报告在过去一个月内休过病假，11.4%的患者报告因MG停止工作（或提前退休）。此外，36.0%的患者需要照料者支持，14.6%的照料者减少了工作时长，13.4%的照料者停止工作。患者和照料者合计的平均生产力损失为每年16,630英镑，主要归因于患者的生产力损失（13,891英镑）。重症MG患者的生产力损失是轻症患者的3.8倍。意大利、西班牙和美国的生产力损失估计有所不同。
MG对患者和照料者工作生产力的影响导致他们中的许多人减少工作时长或提前退休，从而造成显著的生产力损失。这些生产力损失的程度与症状严重程度相关，且因国家而异。
