Weberg R, Berstad A, Aaseth J, Falch J A
Scand J Gastroenterol. 1985 Aug;20(6):741-6. doi: 10.3109/00365528509089205.
Mineral-metabolic side effects of a low dose of a conventional Al-Mg antacid were examined in 10 healthy volunteers, who were given one antacid tablet after the 3 main meals and at bedtime (buffering capacity, 120 mmol/day) for 4 weeks. Compared with the pre-medication state, the following changes of statistical significance occurred during antacid ingestion: increase in urinary excretion of magnesium, calcium, and aluminum; decrease in urinary excretion of phosphate; increase in maximal renal phosphate reabsorption (Tm PO4/GFR); and increase in serum concentration of aluminum. Most of the changes were normalized 3-4 days after cessation of antacid medication. There was no change in intestinal absorption of calcium. The fact that even this low dose of antacids can provoke measurable changes in mineral metabolism, including aluminum absorption, is noteworthy, although we did not see any clinical symptoms from the biochemical changes.
在10名健康志愿者中研究了低剂量传统铝镁抗酸剂的矿物质代谢副作用，这些志愿者在三餐主餐及睡前服用一片抗酸剂（缓冲能力，120 mmol/天），持续4周。与用药前状态相比，服用抗酸剂期间出现了以下具有统计学意义的变化：尿镁、钙和铝排泄增加；尿磷排泄减少；最大肾小管磷重吸收（Tm PO4/GFR）增加；血清铝浓度增加。抗酸剂停药后3 - 4天，大多数变化恢复正常。钙的肠道吸收没有变化。值得注意的是，即使是这种低剂量的抗酸剂也能引起矿物质代谢的可测量变化，包括铝吸收，尽管我们未从生化变化中观察到任何临床症状。
