Calandrelli Rosalinda, Pilato Fabio, Picciotti Pasqualina Maria, Rossi Giorgia, Panfili Marco, Mazzon Giovanni, Tizio Angelo, Rodolico Daniela, Gaudino Simona, Galli Jacopo
Radiology and Neuroradiology Unit, Department of Imaging, Radiation Therapy and Hematology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Acta Otorhinolaryngol Ital. 2025 Apr;45(2):135-143. doi: 10.14639/0392-100X-N3022.
To quantify inner ear fluid changes in patients with audiovestibular deficits by measuring signal intensity values; to correlate the signal intensity values of inner ear structures and audio-vestibular impairment severity.
26 patients with unilateral vestibulocochlear deficits underwent hearing and vestibular assessments and were categorised into severity classes using audiological and vestibular deficit scores. Normalised signal intensity values of inner ear structures were extracted from 3D-T2-WI-MRI scans (nT2mean, nT2Max, nT2min) and signal intensity ratios were calculated using the unaffected ear as a reference.
Asymmetry ratios of nT2Max and nT2mean volumetric intensity values from the cochlea and entire inner ear discriminated severe hearing impairment from lesser deficits and diagnostic performance of nT2mean values was excellent.
Quantitative MRI analysis may be a useful tool to assess the severity of auditory deficits. Asymmetry ratios of nT2mean and nT2Max signal intensity values derived from the cochlea and entire inner labyrinth are surrogate indicators of unilateral cochlear-vestibular deficits and may have potential prognostic value.
通过测量信号强度值来量化患有听觉前庭功能障碍患者的内耳液体变化；将内耳结构的信号强度值与听觉前庭损伤严重程度进行关联。
26例单侧前庭蜗神经功能障碍患者接受听力和前庭评估，并使用听力学和前庭功能缺损评分将其分为不同严重程度等级。从三维T2加权磁共振成像扫描中提取内耳结构的标准化信号强度值（nT2mean、nT2Max、nT2min），并以未受影响的耳朵作为参照计算信号强度比。
耳蜗和整个内耳的nT2Max和nT2mean体积强度值的不对称比可区分重度听力障碍与较轻的功能缺损，且nT2mean值的诊断性能极佳。
定量磁共振成像分析可能是评估听觉功能缺损严重程度的有用工具。源自耳蜗和整个内耳迷路的nT2mean和nT2Max信号强度值的不对称比是单侧耳蜗前庭功能缺损的替代指标，可能具有潜在的预后价值。
