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ABO血型抗原和Rh因子与乳腺癌的关系：一项系统评价和荟萃分析。

Relationship between ABO blood group antigens and Rh factor with breast cancer: A systematic review and meta-analysis.

作者信息

Alchazal Rahaf, Zaitoun Khaled J, Al-Qudah Mohammad, Zaitoun Ghena, Taha Amira M, Saleh Othman, Alqudah Mohammad, Abuawwad Mohammad, Taha Mohammad, Aldalati Abdullah Yousef

机构信息

Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

Oncotarget. 2025 May 9;16:311-326. doi: 10.18632/oncotarget.28718.

DOI:10.18632/oncotarget.28718
PMID:40353794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12068321/
Abstract

BACKGROUND

Breast cancer is a type of cancer that can affect both males and females, but it is widespread among women. Blood types may be associated with breast cancer, as many studies have reported on this relationship but rarely described it. The primary objective of our research is to summarize and analyze the available evidence to produce comprehensive and accurate information that can be used to make evidence-based decisions.

METHODS

Researchers searched for studies on breast cancer patients and ABO blood groups across four major databases: PubMed, Scopus, Web of Science, and Google. The outcomes of the studies were presented as a relative risk and odds ratio with a 95% confidence interval.

RESULTS

Twenty-nine case-control studies with 13029 breast cancer patients. Blood type A was the most common blood type among patients. For blood type A, there was an association with breast cancer (OR = 1.18, 95% CI: 1.03-1.36). Blood types B, AB, and Rh factor showed no significant association with breast cancer (OR = 0.97, 95% CI: 0.86-1.11, OR = 1.05, 95% CI: 0.89-1.25, and OR = 1.14, 95% CI: 0.81-1.60 respectively) in compare to blood type A.

CONCLUSIONS

This study highlights the potential of blood type A as a risk factor for breast cancer compared to blood type O. This relationship was insignificant for blood types B, AB, or Rh. Further studies are needed to understand the mechanisms behind the blood type and breast cancer correlation.

摘要

背景

乳腺癌是一种可影响男性和女性的癌症，但在女性中更为普遍。血型可能与乳腺癌有关，因为许多研究都报道了这种关系，但很少详细描述。我们研究的主要目的是总结和分析现有证据，以产生全面准确的信息，用于做出基于证据的决策。

方法

研究人员在四个主要数据库（PubMed、Scopus、科学网和谷歌）中搜索关于乳腺癌患者和ABO血型的研究。研究结果以相对风险和比值比以及95%置信区间呈现。

结果

有29项病例对照研究，涉及13029名乳腺癌患者。A型血是患者中最常见的血型。对于A型血，与乳腺癌存在关联（比值比=1.18，95%置信区间：1.03 - 1.36）。与A型血相比，B型血、AB型血和Rh因子与乳腺癌无显著关联（比值比分别为0.97，95%置信区间：0.86 - 1.11；比值比为1.05，95%置信区间：0.89 - 1.25；比值比为1.14，95%置信区间：0.81 - 1.60）。

结论

本研究强调了与O型血相比，A型血作为乳腺癌风险因素的可能性。对于B型血、AB型血或Rh因子，这种关系不显著。需要进一步研究以了解血型与乳腺癌相关性背后的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/ef8406703519/oncotarget-16-28718-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/18bc3c0ff53b/oncotarget-16-28718-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/549ce3e93e01/oncotarget-16-28718-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/664f2b3739b9/oncotarget-16-28718-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/ef8406703519/oncotarget-16-28718-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/18bc3c0ff53b/oncotarget-16-28718-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/9d21bd209112/oncotarget-16-28718-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/39234f7922f7/oncotarget-16-28718-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/d10d92ab5efd/oncotarget-16-28718-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/549ce3e93e01/oncotarget-16-28718-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/664f2b3739b9/oncotarget-16-28718-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c97/12068321/ef8406703519/oncotarget-16-28718-g007.jpg

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